Stumbling Blocks in the Investigation of the Relationship Between Age-Related Hearing Loss and Cognitive Impairment.

IF 10.5 1区心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY Perspectives on Psychological Science Pub Date : 2024-01-01 Epub Date: 2023-07-06 DOI:10.1177/17456916231178554

Tetsuya Asakawa, Yunfeng Yang, Zhenxu Xiao, Yirong Shi, Wei Qin, Zhen Hong, Ding Ding

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Abstract

The relationship between age-related hearing loss (ARHL) and cognitive impairment (CI) remains intricate. However, there is no robust evidence from experimental or clinical studies to elucidate their relationship. The key unaddressed questions are (a) whether there is a causal effect of ARHL on CI and (b) whether efficacious treatment of ARHL (such as hearing-aid use) ameliorates CI and dementia-related behavioral symptoms. Because of several methodological and systematic flaws/challenges, rigorous verification has not been conducted. Addressing these stumbling blocks is essential to unraveling the relationship between ARHL and CI, which motivated us to undertake this review. Here, we discuss the methodological problems from the perspectives of potential confounding bias, assessments of CI and ARHL, hearing-aid use, functional-imaging studies, and animal models based on the latest information and our experiences. We also identify potential solutions for each problem from the viewpoints of clinical epidemiology. We believe that "objectivity," specifically the use of more objective behavioral assessments and new computerized technologies, may be the key to improving experimental designs for studying the relationship between ARHL and CI.

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研究老年性听力损失与认知障碍之间关系的绊脚石。

老年性听力损失（ARHL）与认知障碍（CI）之间的关系仍然错综复杂。然而，目前还没有实验或临床研究的有力证据来阐明它们之间的关系。尚未解决的关键问题是：（a）ARHL 对 CI 是否有因果效应；（b）ARHL 的有效治疗（如使用助听器）是否能改善 CI 和痴呆相关的行为症状。由于在方法学和系统性方面存在一些缺陷/挑战，因此尚未进行严格的验证。解决这些绊脚石对于揭示 ARHL 与 CI 之间的关系至关重要，这也是我们开展本综述的动机。在此，我们将根据最新信息和自身经验，从潜在混杂偏差、CI 和 ARHL 评估、助听器使用、功能成像研究和动物模型等角度讨论方法学问题。我们还从临床流行病学的角度找出了每个问题的潜在解决方案。我们认为，"客观性"，特别是使用更客观的行为评估和新的计算机技术，可能是改善研究 ARHL 与 CI 关系的实验设计的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Perspectives on Psychological Science PSYCHOLOGY, MULTIDISCIPLINARY-

CiteScore

22.70

自引率

4.00%

发文量

111

期刊介绍： Perspectives on Psychological Science is a journal that publishes a diverse range of articles and reports in the field of psychology. The journal includes broad integrative reviews, overviews of research programs, meta-analyses, theoretical statements, book reviews, and articles on various topics such as the philosophy of science and opinion pieces about major issues in the field. It also features autobiographical reflections of senior members of the field, occasional humorous essays and sketches, and even has a section for invited and submitted articles. The impact of the journal can be seen through the reverberation of a 2009 article on correlative analyses commonly used in neuroimaging studies, which still influences the field. Additionally, a recent special issue of Perspectives, featuring prominent researchers discussing the "Next Big Questions in Psychology," is shaping the future trajectory of the discipline. Perspectives on Psychological Science provides metrics that showcase the performance of the journal. However, the Association for Psychological Science, of which the journal is a signatory of DORA, recommends against using journal-based metrics for assessing individual scientist contributions, such as for hiring, promotion, or funding decisions. Therefore, the metrics provided by Perspectives on Psychological Science should only be used by those interested in evaluating the journal itself.