Quantification of Chlorate and Perchlorate in a Broad Range of Food Commodities, Including Baby Food, Nutritional Formulas, and Ingredients by LC-MS/MS: First Action AOAC 2022.06.

IF 1.7 4区 农林科学 Q3 CHEMISTRY, ANALYTICAL Journal of AOAC International Pub Date : 2023-11-02 DOI:10.1093/jaoacint/qsad086
José Fernando Huertas-Pérez, Pascal Mottier, Erik Konings, Quentin Baslé, Shi Ying Tan, Monika Kopeć-Durska, Patrycja Zawada, Ashley Griffin, María Guadalupe Sánchez-Calderón, Juan Pablo Silva-Robledo, Lisette Rubio
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引用次数: 0

Abstract

Background: Chlorate is an effective herbicide, but also a byproduct of chlorinating agents used to disinfect water, which is one of the reasons why it is regularly found in food. Perchlorate is a ubiquitous contaminant, which is naturally occurring in the environment but also released from anthropogenic sources such as the industrial use of certain natural fertilizers. Chlorate affects the hematological system, and perchlorate the thyroid.

Objective: Implement and validate a simple and robust analytical method for the accurate determination of chlorate and perchlorate in baby food, infant and adult formulas, and ingredients thereof, which is suited for its application in routine environments where a broad variety of food commodities must be analyzed simultaneously.

Method: Typically, analytes are extracted with a mixture of water, acidified methanol, and dichloromethane. Optionally, for dairy products and byproducts, extraction can be performed with water, acidified methanol, and EDTA, followed by two steps of cleanup (freezing out and dispersive solid-phase extraction with C18 in acetonitrile). Quantitative determination is carried out by isotopic dilution liquid chromatography tandem mass spectrometry (LC-MS/MS).

Results: The method was single-laboratory validated in five Nestlé Quality Assurance Centers (NQACs) in a comprehensive range of representative matrixes of different categories such as baby foods, infant/adult formulas, and ingredients, with results generally in agreement with the acceptance criteria of the Standard Method Performance Requirement (SMPR®) 2021.001 defined by AOAC INTERNATIONAL, in terms of representative matrixes validated, LOQs, trueness, and precision.The data generated during validation show that the method proposed is simple, accurate and robust enough to be implemented and applied in routine environments.

Conclusion: The data generated during validation show that the method proposed is simple, accurate and robust enough to be implemented and applied in routine environments.

Highlights: The AOAC Expert Review Panel approved the present method as AOAC Official First Action 2022.06.

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用LC-MS/MS定量多种食品中的氯酸盐和高氯酸盐,包括婴儿食品、营养配方和配料:第一个行动AOAC 2022.06。
背景:氯酸盐是一种有效的除草剂,也是用于消毒水的氯化剂的副产品,这也是它经常出现在食品中的原因之一。高氯酸盐是一种普遍存在的污染物,它自然存在于环境中,但也从人为来源释放,如某些天然肥料的工业使用。氯酸盐影响血液系统,高氯酸盐影响甲状腺。目的:实现并验证一种简单可靠的分析方法,用于准确测定婴儿食品、婴儿和成人配方奶粉及其成分中的氯酸盐和高氯酸盐,该方法适用于必须同时分析多种食品的常规环境。方法:通常,分析物用水、酸化甲醇和二氯甲烷的混合物提取。可选地,对于乳制品和副产品,可以用水、酸化甲醇和EDTA进行提取,然后进行两步清理(冷冻和用C18在乙腈中分散固相萃取)。通过同位素稀释液相色谱-串联质谱法(LC-MS/MS)进行定量测定。结果:该方法在五个雀巢质量保证中心(NQAC)对不同类别的代表性基质(如婴儿食品、婴儿/成人配方奶粉和成分)进行了单实验室验证,在验证的代表性矩阵、LOQ、真实性和精度方面,结果总体上符合AOAC INTERNATIONAL定义的标准方法性能要求(SMPR®)2021.001的验收标准。验证过程中产生的数据表明,所提出的方法简单、准确、稳健,足以在常规环境中实施和应用。结论:验证过程中产生的数据表明,所提出的方法简单、准确、稳健,足以在常规环境中实施和应用。亮点:AOAC专家审查小组批准本方法为AOAC 2022.06年正式首次行动。
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来源期刊
Journal of AOAC International
Journal of AOAC International 医学-分析化学
CiteScore
3.10
自引率
12.50%
发文量
144
审稿时长
2.7 months
期刊介绍: The Journal of AOAC INTERNATIONAL publishes the latest in basic and applied research in analytical sciences related to foods, drugs, agriculture, the environment, and more. The Journal is the method researchers'' forum for exchanging information and keeping informed of new technology and techniques pertinent to regulatory agencies and regulated industries.
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