Eight Weeks of Physical Training Decreases 2 Years of DNA Methylation Age of Sedentary Women.

IF 1.4 4区教育学 Q3 HOSPITALITY, LEISURE, SPORT & TOURISM Research Quarterly for Exercise and Sport Pub Date : 2024-06-01 Epub Date: 2023-07-19 DOI:10.1080/02701367.2023.2228388

Guilherme da Silva Rodrigues, Isabella Harumi Yonehara Noma, Natália Yumi Noronha, Lígia Moriguchi Watanabe, Andressa Crystine da Silva Sobrinho, João Gabriel Ribeiro de Lima, Chanachai Sae-Lee, Cicero Jonas Rodrigues Benjamim, Carla Barbosa Nonino, Carlos Roberto Bueno

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Abstract

Purpose: The acceleration of epigenetic age is a predictor of mortality and contributes to the increase in chronic diseases. Adherence to a healthy lifestyle is a strategy to reduce epigenetic age. The present study aimed to determine whether eight weeks of combined (aerobic and strength) training (CT) can influence the epigenetic age of women between 50 and 70 years old and the differences in sites and methylated regions. Methods: Eighteen women (AAR_Low: lower age acceleration residual, n = 10; AAR_High: higher age acceleration residual, n = 8) participated in a combined exercise training program (60 minutes, 3× a week) for eight weeks. DNA was extracted from whole blood using the salting out technique. DNA methylation was performed using the array technique (Illumina's Infinium Methylation BeadChip 850k). We used the DNA Methylation Age Calculator platform to calculate the biological epigenetic age. Two-way ANOVA followed by FISHER LSD posthoc was Applied, adopting p < .05. Results: After eight weeks of CT, there were no changes to the epigenetic age acceleration for the AAR_Low group (PRE: -2.3 ± 3.2 to POST: -2.3 ± 3.6). However, the AAR_High group significantly decreased the age acceleration (PRE: 3.6 ± 2.6 to POST: 2.2 ± 2.7) (group effect, p = .01; time effect, p = .31; group vs. time effect, p = .005). Conclusion: CT for eight weeks benefits the epigenetic clock of women with the most accelerated age.

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八周的体育训练可降低久坐妇女两年的 DNA 甲基化年龄。

目的：表观遗传年龄的加速是死亡率的预测因素，也是慢性疾病增加的原因之一。坚持健康的生活方式是降低表观遗传年龄的一种策略。本研究旨在确定为期八周的联合（有氧和力量）训练（CT）是否会影响 50 至 70 岁女性的表观遗传年龄，以及影响部位和甲基化区域的差异。研究方法18名女性（AARLow：低年龄加速度残差，n = 10；AARHigh：高年龄加速度残差，n = 8）参加了为期八周的综合运动训练计划（每周3次，每次60分钟）。采用盐析技术从全血中提取 DNA。采用阵列技术（Illumina 的 Infinium Methylation BeadChip 850k）进行 DNA 甲基化。我们使用 DNA 甲基化年龄计算器平台计算生物表观遗传年龄。应用双向方差分析和 FISHER LSD 后验，采用 p 结果：经过八周的 CT 治疗后，AARLow 组的表观遗传年龄加速度没有变化（前：-2.3 ± 3.2 到后：-2.3 ± 3.6）。然而，AARHigh 组的年龄加速显著降低（PRE：3.6 ± 2.6 至 POST：2.2 ± 2.7）（组效应，p = .01；时间效应，p = .31；组与时间效应，p = .005）。结论持续八周的 CT 对年龄增长最快的女性的表观遗传时钟有好处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research Quarterly for Exercise and Sport 社会科学-心理学

CiteScore

4.30

自引率

0.00%

发文量

125

审稿时长

6-12 weeks

期刊介绍： Research Quarterly for Exercise and Sport publishes research in the art and science of human movement that contributes significantly to the knowledge base of the field as new information, reviews, substantiation or contradiction of previous findings, development of theory, or as application of new or improved techniques. The goals of RQES are to provide a scholarly outlet for knowledge that: (a) contributes to the study of human movement, particularly its cross-disciplinary and interdisciplinary nature; (b) impacts theory and practice regarding human movement; (c) stimulates research about human movement; and (d) provides theoretical reviews and tutorials related to the study of human movement. The editorial board, associate editors, and external reviewers assist the editor-in-chief. Qualified reviewers in the appropriate subdisciplines review manuscripts deemed suitable. Authors are usually advised of the decision on their papers within 75–90 days.