Immunologically relevant effects of radiation therapy on the tumor microenvironment.

IF 5.6 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Essays in biochemistry Pub Date : 2023-09-28 DOI:10.1042/EBC20220248

Claudia Galassi, Vanessa Klapp, Silvia C Formenti, Sandra Demaria, Lorenzo Galluzzi

引用次数: 0

Abstract

Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.

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放射治疗对肿瘤微环境的免疫学相关影响。

一个多世纪以来，局灶性放射治疗（RT）已成功应用于临床治疗多种类型的癌症。除了对恶性细胞的细胞毒性优先于未转化的恶性细胞外，RT还引发了许多微环境变化，这些变化似乎是其治疗效果的因素。在此，我们简要讨论了RT引起的免疫刺激和免疫抑制微环境变化及其对宿主免疫系统识别肿瘤的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Essays in biochemistry 生物-生化与分子生物学

CiteScore

10.50

自引率

0.00%

发文量

105

审稿时长

>12 weeks

期刊介绍： Essays in Biochemistry publishes short, digestible reviews from experts highlighting recent key topics in biochemistry and the molecular biosciences. Written to be accessible for those not yet immersed in the subject, each article is an up-to-date, self-contained summary of the topic. Bridging the gap between the latest research and established textbooks, Essays in Biochemistry will tell you what you need to know to begin exploring the field, as each article includes the top take-home messages as summary points. Each issue of the journal is guest edited by a key opinion leader in the area, and whether you are continuing your studies or moving into a new research area, the Journal gives a complete picture in one place. Essays in Biochemistry is proud to publish Understanding Biochemistry, an essential online resource for post-16 students, teachers and undergraduates. Providing up-to-date overviews of key concepts in biochemistry and the molecular biosciences, the Understanding Biochemistry issues of Essays in Biochemistry are published annually in October.

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