The role of biomarkers in stage III non-small cell lung cancer.

IF 2.9 3区医学 Q2 RESPIRATORY SYSTEM Expert Review of Respiratory Medicine Pub Date : 2023-01-01 Epub Date: 2023-06-15 DOI:10.1080/17476348.2023.2223985

Rafael Rosell, María González-Cao, Masaoki Ito, Mariacarmela Santarpia, Andrés Aguilar, Jordi Codony-Servat

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引用次数: 1

Abstract

Introduction: Stage III non-small cell lung cancer (NSCLC) is a composite of the regional spread of lung cancer with different levels of potential lymph node involvement and tumor size that often deem the stage at time of diagnosis to be unresectable and suitable for chemoradiation plus consolidation immunotherapy with durvalumab for 12 months. Chemoradiation plus durvalumab consolidation yielded a landmark 49.2% 5-year overall survival in unresectable NSCLC.

Areas covered: Sub-optimal results lead us to focus on the mechanisms of resistance responsible for intractability in a significant proportion of cases that fail with chemoradiation and immunotherapy. In stage III NSCLC it is opportune to explore the accumulated evidence on ferroptosis resistance that can lead to cancer progression and metastasis. Strong data shows that three anti-ferroptosis pathways are principally involved in resistance to chemotherapy, radiation, and immunotherapy.

Expert opinion: Because a large part of stage III NSCLCs is resistant to chemoradiation and durvalumab consolidation, a ferroptosis-based therapeutic approach, combined with standard-of-care therapy, can lead to improved clinical outcomes in patients diagnosed with stage III and possibly stage IV NSCLCs.

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生物标志物在癌症III期非小细胞肺癌中的作用。

简介：III期非小细胞肺癌癌症（NSCLC）是癌症区域扩散的复合物，具有不同程度的潜在淋巴结受累和肿瘤大小，通常认为诊断时的阶段是不可切除的，适合放化疗加杜伐鲁单抗巩固免疫治疗12 月。化疗加杜伐单抗联合治疗在不可切除的NSCLC中获得了里程碑式的49.2%的5年总生存率。所涵盖的领域：次优结果使我们关注在化疗和免疫治疗失败的很大一部分病例中导致难治性的耐药性机制。在III期NSCLC中，探索铁蛋白脱羧酶耐药性的积累证据是合适的，铁蛋白脱氨酶耐药性可导致癌症进展和转移。强有力的数据表明，三种抗脱铁性贫血途径主要涉及对化疗、放疗和免疫疗法的耐药性。专家意见：由于III期NSCLC的很大一部分对放化疗和杜伐单抗合并具有耐药性，因此基于脱铁性贫血的治疗方法与标准护理治疗相结合，可以改善诊断为III期和IV期NSCLC患者的临床结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Respiratory Medicine RESPIRATORY SYSTEM-

CiteScore

6.80

自引率

2.60%

发文量

期刊介绍： Coverage will include the following key areas: - Prospects for new and emerging therapeutics - Epidemiology of disease - Preventive strategies - All aspects of COPD, from patient self-management to systemic effects of the disease and comorbidities - Improved diagnostic methods, including imaging techniques, biomarkers and physiological tests. - Advances in the treatment of respiratory infections and drug resistance issues - Occupational and environmental factors - Progress in smoking intervention and cessation methods - Disease and treatment issues for defined populations, such as children and the elderly - Respiratory intensive and critical care - Updates on the status and advances of specific disease areas, including asthma, HIV/AIDS-related disease, cystic fibrosis, COPD and sleep-disordered breathing morbidity