The gut microbiota is an emerging target for improving brain health during ageing.

Gut microbiome (Cambridge, England) Pub Date : 2023-01-01 Epub Date: 2022-12-12 DOI:10.1017/gmb.2022.11
Marcus Boehme, Katherine Elizabeth Guzzetta, Caroline Wasén, Laura Michelle Cox
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Abstract

The gut microbiota plays crucial roles in maintaining the health and homeostasis of its host throughout lifespan, including through its ability to impact brain function and regulate behaviour during ageing. Studies have shown that there are disparate rates of biologic ageing despite equivalencies in chronologic age, including in the development of neurodegenerative diseases, which suggests that environmental factors may play an important role in determining health outcomes in ageing. Recent evidence demonstrates that the gut microbiota may be a potential novel target to ameliorate symptoms of brain ageing and promote healthy cognition. This review highlights the current knowledge around the relationships between the gut microbiota and host brain ageing, including potential contributions to age-related neurodegenerative diseases. Furthermore, we assess key areas for which gut microbiota-based strategies may present as opportunities for intervention.

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肠道微生物群是改善老年期大脑健康的一个新兴目标。
肠道微生物群在维持宿主整个生命周期的健康和平衡方面发挥着至关重要的作用,包括通过其在衰老过程中影响大脑功能和调节行为的能力。研究表明,尽管实际年龄相同,但生物老化的速度却有差异,包括神经退行性疾病的发病率,这表明环境因素可能在决定老化过程中的健康结果方面发挥着重要作用。最近的证据表明,肠道微生物群可能是改善脑老化症状和促进健康认知的潜在新目标。本综述重点介绍了目前有关肠道微生物群与宿主大脑老化之间关系的知识,包括对与年龄相关的神经退行性疾病的潜在贡献。此外,我们还评估了基于肠道微生物群的策略可能提供干预机会的关键领域。
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