Bloodstream infections and antibiotic resistance patterns: a six-year surveillance study from southern Italy.

IF 4.9 4区 医学 Q1 PARASITOLOGY Pathogens and Global Health Pub Date : 2023-06-01 Epub Date: 2022-10-03 DOI:10.1080/20477724.2022.2129161
F Foglia, M T Della Rocca, C Melardo, B M Nastri, M Manfredini, F Montella, A De Filippis, E Finamore, Massimiliano Galdiero
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引用次数: 4

Abstract

Bloodstream infections (BSI) are associated with high morbidity and mortality. This study aimed to describe the epidemiology of BSI and antimicrobial resistance patterns amongst its common bacterial causes. We conducted a retrospective record review of blood culture results of patients hospitalized with BSI at University Hospital 'L. Vanvitelli' from 2016 to 2021. For each patient records were obtained from the database using microbiological information. Gram-positive bacteria were the most predominant pathogens followed by Gram-negative bacteria. Among all isolates, bacterial pathogens most frequently identified included coagulase-negative Staphylococci (CoNS), Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and enterococci. We noted a general decrease in antimicrobial resistance amongst BSI pathogens in the latter years of the study. High levels of macrolide and aminoglycoside resistance amongst CoNS were reported. Carbapenem resistance amongst E. coli was barely reported, while resistance rates amongst K. pneumoniae declined considerably between 2018 and 2021. The prevalence of methicillin-resistant S. aureus decreased during the study period while that of methicillin-resistant CoNS remained relatively high throughout. The prevalence of extended spectrum ß-lactamase - producing E. coli increased considerably between 2016 and 2018 but showed a slight decrease thereafter. Conversely, there was a general decline in the resistant rates of extended spectrum ß-lactamase - producing K. pneumoniae between 2016 and 2018 with a similar trend being noted for carbapenem resistance in K. pneumoniae. Continuously monitoring the changes in the trends in BSI microbiological profiles, including pathogen profiles and the associated antibiotic resistance patterns, can help diagnostic approaches, treatment strategies and prevention programs.

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血流感染和抗生素耐药性模式:来自意大利南部的一项为期六年的监测研究。
血流感染(BSI)与高发病率和死亡率相关。本研究旨在描述BSI的流行病学及其常见细菌耐药性模式。我们对L大学医院因BSI住院的患者的血液培养结果进行了回顾性记录审查。Vanvitelli’从2016年到2021年。使用微生物信息从数据库中获得每个患者的记录。革兰氏阳性菌是最主要的病原体,其次是革兰氏阴性菌。在所有分离株中,最常见的细菌病原体包括凝固酶阴性葡萄球菌(CoNS)、肺炎克雷伯菌、金黄色葡萄球菌、铜绿假单胞菌、大肠杆菌和肠球菌。我们注意到,在研究的后期,BSI病原体的抗微生物耐药性普遍下降。据报道,CoNS中存在高水平的大环内酯类和氨基糖苷类耐药性。大肠杆菌对碳青霉烯的耐药性几乎没有报道,而肺炎克雷伯菌的耐药性在2018年至2021年间大幅下降。耐甲氧西林金黄色葡萄球菌的患病率在研究期间下降,而耐甲氧青霉素CoNS的患病率始终相对较高。2016年至2018年间,产超广谱ß-内酰胺酶大肠杆菌的流行率大幅上升,但此后略有下降。相反,在2016年至2018年间,产生超广谱ß-内酰胺酶的肺炎克雷伯菌的耐药性普遍下降,肺炎克雷伯菌对碳青霉烯的耐药性也有类似的趋势。持续监测BSI微生物谱的趋势变化,包括病原体谱和相关的抗生素耐药性模式,可以帮助诊断方法、治疗策略和预防计划。
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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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