{"title":"Leptin and male fertility: unraveling the molecular pathways, receptor functions, and therapeutic potential.","authors":"Himanshu Arora","doi":"10.1016/j.molmed.2023.06.010","DOIUrl":null,"url":null,"abstract":"<p><p>Leptin, an adipokine hormone, is a critical regulator of energy homeostasis, appetite, and metabolism. Recent advances have elucidated its role in male fertility. This forum provides an overview of the interplay between leptin, its receptors, and signaling pathways in the context of male fertility, revealing its multifaceted impact on reproductive health.</p>","PeriodicalId":23263,"journal":{"name":"Trends in molecular medicine","volume":null,"pages":null},"PeriodicalIF":12.8000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in molecular medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.molmed.2023.06.010","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/7/21 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Leptin, an adipokine hormone, is a critical regulator of energy homeostasis, appetite, and metabolism. Recent advances have elucidated its role in male fertility. This forum provides an overview of the interplay between leptin, its receptors, and signaling pathways in the context of male fertility, revealing its multifaceted impact on reproductive health.
期刊介绍：
Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.
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