Repurposing Drugs: An Empowering Approach to Drug Discovery and Development.

IF 1.7 Q3 PHARMACOLOGY & PHARMACY Drug Research Pub Date : 2023-11-01 Epub Date: 2023-07-21 DOI:10.1055/a-2095-0826
Sahil Kumar, Vandana Roy
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引用次数: 1

Abstract

Drug discovery and development is a time-consuming and costly procedure that necessitates a substantial effort. Drug repurposing has been suggested as a method for developing medicines that takes less time than developing brand new medications and will be less expensive. Also known as drug repositioning or re-profiling, this strategy has been in use from the time of serendipitous drug discoveries to the modern computer aided drug designing and use of computational chemistry. In the light of the COVID-19 pandemic too, drug repurposing emerged as a ray of hope in the dearth of available medicines. Data availability by electronic recording, libraries, and improvements in computational techniques offer a vital substrate for systemic evaluation of repurposing candidates. In the not-too-distant future, it could be possible to create a global research archive for us to access, thus accelerating the process of drug development and repurposing. This review aims to present the evolution, benefits and drawbacks including current approaches, key players and the legal and regulatory hurdles in the field of drug repurposing. The vast quantities of available data secured in multiple drug databases, assisting in drug repurposing is also discussed.

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重新利用药物:药物发现和开发的授权方法。
药物发现和开发是一个耗时且成本高昂的过程,需要付出大量努力。药物再利用被认为是一种开发药物的方法,这种方法比开发全新药物花费的时间更短,而且成本更低。这种策略也被称为药物重新定位或重新分析,从偶然发现药物到现代计算机辅助药物设计和计算化学的使用,这种策略一直在使用。在新冠肺炎大流行的背景下,药物再利用也成为可用药物短缺的一线希望。通过电子记录、图书馆和计算技术的改进提供的数据可用性为重新调整候选人用途的系统评估提供了重要的基础。在不久的将来,有可能创建一个全球研究档案供我们访问,从而加快药物开发和重新利用的进程。本综述旨在介绍药物再利用领域的演变、优点和缺点,包括当前的方法、关键参与者以及法律和监管障碍。还讨论了在多个药物数据库中保护的大量可用数据,以帮助药物重新利用。
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来源期刊
Drug Research
Drug Research PHARMACOLOGY & PHARMACY-
CiteScore
3.50
自引率
0.00%
发文量
67
期刊介绍: Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine and the application of biological discoveries in the development of drugs for use in the clinical environment. Articles and experimental data from across the field of drug research address not only the issue of drug discovery, but also the mathematical and statistical methods for evaluating results from industrial investigations and clinical trials. Publishing twelve times a year, Drug Research includes original research articles as well as reviews, commentaries and short communications in the following areas: analytics applied to clinical trials chemistry and biochemistry clinical and experimental pharmacology drug interactions efficacy testing pharmacodynamics pharmacokinetics teratology toxicology.
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