VDR gene ApaI polymorphism and risk of postmenopausal osteoporosis: a meta-analysis from 22 studies.

IF 2.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY Climacteric Pub Date : 2023-12-01 Epub Date: 2023-07-21 DOI:10.1080/13697137.2023.2233421

B Wang, H Li, C Yang, R Nie, X Zhang, C Pu

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Abstract

Objective: The ApaI polymorphism (G > T, rs7975232) of the vitamin D receptor (VDR) gene in the risk of postmenopausal osteoporosis has been widely researched, and the results have yielded conflicts. Therefore, we performed an updated pooled analysis to comprehensively assess the association between VDR ApaI polymorphism and postmenopausal osteoporosis risk.

Methods: We searched eligible studies about ApaI polymorphism and osteoporosis through the PubMed, Embase, CNKI and Wanfang databases; case-control studies containing available genotype frequencies of A/a were chosen. We used the odds ratio with 95% confidence interval to assess the strength of this association. Sensitivity analysis and publication bias assessment were performed. Trial sequential analysis (TSA) was performed to evaluate a sufficient sample.

Results: Twenty-two studies assessed the relationship between ApaI polymorphism and the risk of osteoporosis in postmenopausal women. The comprehensive analyses showed no significant association for ApaI polymorphism with postmenopausal osteoporosis in the overall population, equally valid for Asian and Caucasian subgroups with any genetic model. TSA still indicated the results were robust.

Conclusion: The present meta-analysis suggests that the VDR ApaI genotype may not affect the risk of postmenopausal osteoporosis in Asians and Caucasians.

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VDR基因ApaI多态性与绝经后骨质疏松风险:来自22项研究的荟萃分析

目的:维生素D受体(VDR)基因ApaI多态性(G > T, rs7975232)与绝经后骨质疏松风险的关系已被广泛研究，但结果存在矛盾。因此，我们进行了一项最新的汇总分析，以全面评估VDR ApaI多态性与绝经后骨质疏松症风险之间的关系。方法:通过PubMed、Embase、CNKI和万方数据库检索ApaI多态性与骨质疏松症相关的符合条件的研究;选择含有A/ A可用基因型频率的病例对照研究。我们使用95%置信区间的优势比来评估这种关联的强度。进行敏感性分析和发表偏倚评估。进行试验序列分析(TSA)以评估足够的样本。结果:22项研究评估了ApaI多态性与绝经后妇女骨质疏松症风险之间的关系。综合分析显示ApaI多态性与绝经后骨质疏松症在总体人群中无显著关联，对任何遗传模型的亚洲和高加索亚群同样有效。运输安全管理局仍然表示，结果是稳健的。结论:本荟萃分析表明，VDR ApaI基因型可能不会影响亚洲人和高加索人绝经后骨质疏松症的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.