Cholesterol Metabolism in Aging and Age-Related Disorders.

IF 12.1 1区 医学 Q1 NEUROSCIENCES Annual review of neuroscience Pub Date : 2023-07-10 DOI:10.1146/annurev-neuro-091922-034237
Gesine Saher
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引用次数: 3

Abstract

All mammalian cell membranes contain cholesterol to maintain membrane integrity. The transport of this hydrophobic lipid is mediated by lipoproteins. Cholesterol is especially enriched in the brain, particularly in synaptic and myelin membranes. Aging involves changes in sterol metabolism in peripheral organs and also in the brain. Some of those alterations have the potential to promote or to counteract the development of neurodegenerative diseases during aging. Here, we summarize the current knowledge of general principles of sterol metabolism in humans and mice, the most widely used model organism in biomedical research. We discuss changes in sterol metabolism that occur in the aged brain and highlight recent developments in cell type-specific cholesterol metabolism in the fast-growing research field of aging and age-related diseases, focusing on Alzheimer's disease. We propose that cell type-specific cholesterol handling and the interplay between cell types critically influence age-related disease processes.

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衰老和年龄相关疾病中的胆固醇代谢。
所有哺乳动物的细胞膜都含有胆固醇以维持细胞膜的完整性。这种疏水脂质的运输是由脂蛋白介导的。胆固醇在大脑中尤其丰富,尤其是在突触和髓鞘膜中。衰老涉及到外周器官和大脑中固醇代谢的变化。其中一些改变有可能促进或抵消衰老过程中神经退行性疾病的发展。在这里,我们总结了目前在生物医学研究中应用最广泛的模式生物——人类和小鼠体内固醇代谢的一般原理。我们讨论了老年大脑中发生的胆固醇代谢变化,并重点介绍了衰老和年龄相关疾病快速发展的研究领域中细胞类型特异性胆固醇代谢的最新进展,重点是阿尔茨海默病。我们提出细胞类型特异性胆固醇处理和细胞类型之间的相互作用对年龄相关疾病过程具有重要影响。
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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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