Safety of Alprazolam Use in Pregnancy in Western Australia: A Retrospective Cohort Study Using Linked Health Data.

IF 2.1 4区 医学 Q2 PSYCHOLOGY, CLINICAL Journal of psychoactive drugs Pub Date : 2024-09-01 Epub Date: 2023-07-28 DOI:10.1080/02791072.2023.2241465
Erin Kelty, Kate Chitty, David B Preen
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Abstract

The use of alprazolam in pregnancy can adversely affect maternal and neonatal health. This study examined neonatal outcomes following exposure to alprazolam in pregnancy. Women prescribed alprazolam during pregnancy (n = 48) between 2014 and 2018 were identified from routinely-collected state administrative prescribing records and perinatal data. Two comparison groups of women; 1) prescribed alprazolam outside of pregnancy (n = 96) and 2) women never prescribed alprazolam (n = 96) were also identified. The health of women and their children was examined using administrative hospital, mortality and perinatal data and compared to the comparison groups using generalized linear models. Prenatal alprazolam exposure was not associated with a reduction in average birth weight or gestational age. However, neonates prenatally exposed to alprazolam were more likely be classified as having low birth weight for gestational age compared with alprazolam comparison group (OR: 4.46, 95% CI: 1.54-12.95) and the non-alprazolam comparison group (OR: 3.27, 95% CI: 1.22-8.79). There were no cases of perinatal mortality or floppy baby syndrome in alprazolam-exposed neonates. While the use of alprazolam during pregnancy was not associated with an increased risk of severe adverse neonatal outcomes (e.g. perinatal mortality), it was associated with neonates being born with a low birth weight for gestational age.

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西澳大利亚妊娠期使用阿普唑仑的安全性:一项使用关联健康数据的回顾性队列研究。
妊娠期使用阿普唑仑会对产妇和新生儿的健康产生不利影响。本研究检查了妊娠期接触阿普唑仑后新生儿的结局。妇女在怀孕期间服用阿普唑仑(n = 48)是从常规收集的州行政处方记录和围产期数据中确定的。两个妇女比较组;1) 妊娠期外开具的阿普唑仑(n = 96)和2)女性从未开过阿普唑仑(n = 96)。使用医院管理、死亡率和围产期数据检查妇女及其子女的健康状况,并使用广义线性模型与对照组进行比较。产前暴露于阿普唑仑与平均出生体重或胎龄的降低无关。然而,与阿普唑仑对照组(OR:4.46,95%CI:1.54-12.95)和非阿普唑林对照组(OR:3.27,95%CI:1.22-8.79)相比,产前接触阿普唑拉姆的新生儿更有可能被归类为胎龄低出生体重儿。虽然在妊娠期间使用阿普唑仑与新生儿严重不良后果(如围产期死亡率)的风险增加无关,但它与新生儿出生时胎龄低出生体重有关。
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来源期刊
CiteScore
5.30
自引率
7.10%
发文量
62
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