Bioactive compounds from Cordyceps and their therapeutic potential.

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Biotechnology Pub Date : 2024-08-01 Epub Date: 2023-07-30 DOI:10.1080/07388551.2023.2231139
Kondapalli Vamsi Krishna, Rutwick Surya Ulhas, Alok Malaviya
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Abstract

The Clavicipitaceae family's largest and most diverse genus is Cordyceps. They are most abundant and diverse in humid temperate and tropical forests and have a wide distribution in: Europe, North America, and East and Southeast Asian countries, particularly: Bhutan, China, Japan, Nepal, Korea, Thailand, Vietnam, Tibet, and the Himalayan region of India, and Sikkim. It is a well-known parasitic fungus that feeds on insects and other arthropods belonging to 10 different orders. Over 200 bioactive metabolites, that include: nucleotides and nucleosides, polysaccharides, proteins, polypeptides, amino acids, sterols, and fatty acids, among others have been extracted from Cordyceps spp. demonstrating the phytochemical richness of this genus. These components have been associated with a variety of pharmacological effects, including: anti-microbial, anti-apoptotic, anti-cancer, anti-inflammatory, antioxidant, and immunomodulatory activities. In this paper, the bioactivity of various classes of metabolites produced by Cordyceps spp., and their therapeutic properties have been reviewed in an attempt to update the existing literature. Furthermore, one of its nucleoside and a key bioactive compound, cordycepin has been critically elaborated with regard to its biosynthesis pathway and the recently proposed protector-protégé mechanism as well as various biological and pharmacological effects, such as: suppression of purine and nucleic acid biosynthesis, induction of apoptosis, and cell cycle regulation with their mechanism of action. This review provides current knowledge on the bioactive potential of Cordyceps spp.

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冬虫夏草中的生物活性化合物及其治疗潜力。
冬虫夏草科最大和最多样化的属是冬虫夏草属。冬虫夏草在湿润的温带和热带森林中最为丰富多样,广泛分布于欧洲、北美、东亚和东南亚国家,特别是不丹、中国、日本、尼泊尔、韩国、泰国、越南、西藏、印度喜马拉雅地区和锡金。它是一种著名的寄生真菌,以 10 种不同目的昆虫和其他节肢动物为食。从冬虫夏草中提取的生物活性代谢物超过 200 种,包括核苷酸和核苷、多糖、蛋白质、多肽、氨基酸、甾醇和脂肪酸等,显示了该属植物化学物质的丰富性。这些成分具有多种药理作用,包括:抗微生物、抗凋亡、抗癌、抗炎、抗氧化和免疫调节活性。本文综述了冬虫夏草属植物产生的各类代谢物的生物活性及其治疗特性,试图更新现有文献。此外,还对冬虫夏草中的一种核苷和关键生物活性化合物--虫草素,就其生物合成途径和最近提出的保护者-保护者机制,以及各种生物和药理作用(如抑制嘌呤和核酸的生物合成、诱导细胞凋亡和细胞周期调节)及其作用机制进行了批判性阐述。本综述介绍了目前有关冬虫夏草属植物生物活性潜力的知识。
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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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