Prevalence of Histological Characteristics of Breast Cancer in Rwanda in Relation to Age and Tumor Stages.

IF 3 4区 医学 Q3 Biochemistry, Genetics and Molecular Biology Hormones & Cancer Pub Date : 2020-10-01 Epub Date: 2020-08-09 DOI:10.1007/s12672-020-00393-3
Jeanne P Uyisenga, Yvan Butera, Ahmed Debit, Claire Josse, Costas C Ainhoa, Emile Karinganire, Aimee P Cyuzuzo, Nicole Umurungi, Yves Kalinijabo, Simeon Uwimana, Leon Mutesa, Vincent Bours
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Abstract

Breast cancer is a complex disease, and it is the most common cause of morbidity and mortality among women worldwide. In Sub-Saharan Africa, the clinical characteristics and tumor profiles of breast cancer are still unknown. In the present study we aimed to determine breast tumor profiles of the Rwandan patients in relation to age and tumor stages. We compare our findings to related results from other sub-Saharan Africa studies. Data on age at diagnosis, tumor stage, and hormonal profiles of 138 patients diagnosed between January 2015 and December 2018 were retrospectively retrieved from electronic medical records at three referral hospitals in Rwanda. We compared our results to related findings reported in other Sub-Saharan African countries. All statistical analyses were done using SPSS Inc., Chicago, IL, USA, version 20 and R software languages. The mean age at diagnosis was 49.7 years (SD = 13) and ranged from 17 to 86 years. The majority of patients (57.2%) were diagnosed before 50 years of age compared with 42.8% aged > 50 years. Tumor stage III was the commonest accounting for 62% followed by stage II with 24.8%. The distribution of breast tumor subtypes was ER-, PR-, HER2-: 37.7%; ER+, PR+, HER2-: 31.2%; ER-, PR-, HER2+: 14.5%; ER+, PR+, HER2+: 5.1%; and other subtypes represented 11.6%. There was no statistically significant difference in age and tumor stages between the molecular subtypes. Our findings revealed the predominance of hormonal negative tumors among Rwandan patients with breast cancer. Triple negative was found to be the most common breast tumor subtype regardless of age and tumor stage. Larger prospective studies could examine genetics and environmental factors that may play a role in the differences of tumor characteristics in Sub-Saharan populations.

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卢旺达乳腺癌组织学特征与年龄和肿瘤分期的关系。
乳腺癌是一种复杂的疾病,也是全世界妇女发病和死亡的最常见原因。在撒哈拉以南非洲地区,乳腺癌的临床特征和肿瘤概况仍不为人知。在本研究中,我们旨在确定卢旺达患者的乳腺肿瘤特征与年龄和肿瘤分期的关系。我们将研究结果与其他撒哈拉以南非洲地区的相关研究结果进行了比较。我们从卢旺达三家转诊医院的电子病历中回顾性地检索了2015年1月至2018年12月期间确诊的138名患者的诊断年龄、肿瘤分期和激素特征数据。我们将研究结果与其他撒哈拉以南非洲国家报告的相关结果进行了比较。所有统计分析均使用美国伊利诺伊州芝加哥市的 SPSS 公司 20 版和 R 软件语言进行。确诊时的平均年龄为 49.7 岁(SD = 13),从 17 岁到 86 岁不等。大多数患者(57.2%)的确诊年龄在 50 岁之前,而大于 50 岁的患者占 42.8%。肿瘤分期最常见的是 III 期,占 62%,其次是 II 期,占 24.8%。乳腺肿瘤亚型的分布为:ER-、PR-、HER2-:37.7%; ER+, PR+, HER2-:31.2%;ER-、PR-、HER2+:14.5%;ER+、PR+、HER2+:5.1%;其他亚型占 11.6%。各分子亚型之间在年龄和肿瘤分期上没有明显的统计学差异。我们的研究结果表明,在卢旺达乳腺癌患者中,激素阴性肿瘤占多数。三阴性是最常见的乳腺肿瘤亚型,与年龄和肿瘤分期无关。更大规模的前瞻性研究可以对可能导致撒哈拉以南人口肿瘤特征差异的遗传和环境因素进行研究。
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来源期刊
Hormones & Cancer
Hormones & Cancer ONCOLOGY-ENDOCRINOLOGY & METABOLISM
CiteScore
4.60
自引率
0.00%
发文量
0
期刊介绍: Hormones and Cancer is a unique multidisciplinary translational journal featuring basic science, pre-clinical, epidemiological, and clinical research papers. It covers all aspects of the interface of Endocrinology and Oncology. Thus, the journal covers two main areas of research: Endocrine tumors (benign & malignant tumors of hormone secreting endocrine organs) and the effects of hormones on any type of tumor. We welcome all types of studies related to these fields, but our particular attention is on translational aspects of research. In addition to basic, pre-clinical, and epidemiological studies, we encourage submission of clinical studies including those that comprise small series of tumors in rare endocrine neoplasias and/or negative or confirmatory results provided that they significantly enhance our understanding of endocrine aspects of oncology. The journal does not publish case studies.
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Welcome from the new Discover Oncology journal : Editorial - 28th December, 2020. Nuclear PDCD4 Expression Defines a Subset of Luminal B-Like Breast Cancers with Good Prognosis. Prevalence of Histological Characteristics of Breast Cancer in Rwanda in Relation to Age and Tumor Stages. The Thyroid Tumor Microenvironment: Potential Targets for Therapeutic Intervention and Prognostication. Outcome of Clinical Genetic Testing in Patients with Features Suggestive for Hereditary Predisposition to PTH-Mediated Hypercalcemia.
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