Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum-based dental implants

IF 2.4 4区生物学 Q2 DEVELOPMENTAL BIOLOGY genesis Pub Date : 2023-04-17 DOI:10.1002/dvg.23514

Mari M. Saito, Kazuo Onuma, Yasuo Yamakoshi

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引用次数: 2

Abstract

The cementum is the outermost layer of hard tissue covering the dentin within the root portion of the teeth. It is the only hard tissue with a specialized structure and function that forms a part of both the teeth and periodontal tissue. As such, cementum is believed to be critical for periodontal tissue regeneration. In this review, we discuss the function and histological structure of the cementum to promote crystal engineering with a biochemical approach in cementum regenerative medicine. We review the microstructure of enamel and bone while discussing the mechanism underlying apatite crystal formation to infer the morphology of cementum apatite crystals and their complex structure with collagen fibers. Finally, the limitations of the current dental implant treatments in clinical practice are explored from the perspective of periodontal tissue regeneration. We anticipate the possibility of advancing periodontal tissue regenerative medicine via cementum regeneration using a combination of material science and biochemical methods.

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牙骨质是牙周组织再生的关键：新型牙骨质基牙种植体的磷灰石微观结构综述。

牙骨质是覆盖牙齿根部牙本质的最外层硬组织。它是唯一一种具有特殊结构和功能的硬组织，构成牙齿和牙周组织的一部分。因此，牙骨质被认为是牙周组织再生的关键。在这篇综述中，我们讨论了牙骨质的功能和组织结构，以促进生物化学方法在牙骨质再生医学中的晶体工程。我们回顾了牙釉质和骨骼的微观结构，同时讨论了磷灰石晶体形成的机制，以推断牙骨质磷灰石晶体的形态及其与胶原纤维的复杂结构。最后，从牙周组织再生的角度探讨了目前种植牙治疗在临床实践中的局限性。我们预计通过牙骨质再生，结合材料科学和生物化学方法，推进牙周组织再生医学的可能性。

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来源期刊

genesis 生物-发育生物学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： As of January 2000, Developmental Genetics was renamed and relaunched as genesis: The Journal of Genetics and Development, with a new scope and Editorial Board. The journal focuses on work that addresses the genetics of development and the fundamental mechanisms of embryological processes in animals and plants. With increased awareness of the interplay between genetics and evolutionary change, particularly during developmental processes, we encourage submission of manuscripts from all ecological niches. The expanded numbers of genomes for which sequencing is being completed will facilitate genetic and genomic examination of developmental issues, even if the model system does not fit the “classical genetic” mold. Therefore, we encourage submission of manuscripts from all species. Other areas of particular interest include: 1) the roles of epigenetics, microRNAs and environment on developmental processes; 2) genome-wide studies; 3) novel imaging techniques for the study of gene expression and cellular function; 4) comparative genetics and genomics and 5) animal models of human genetic and developmental disorders. genesis presents reviews, full research articles, short research letters, and state-of-the-art technology reports that promote an understanding of the function of genes and the roles they play in complex developmental processes.