Medium-vessel and large-vessel vasculitis in children.

IF 5.2 2区医学 Q1 RHEUMATOLOGY Current opinion in rheumatology Pub Date : 2023-09-01 DOI:10.1097/BOR.0000000000000955

Christiaan Scott, Raphaella Stander, Frank Phoya

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Abstract

Purpose of review: This article serves as an up-to-date examination of the latest findings in the field of paediatric large-vessel and medium-vessel vasculitis.

Recent findings: Over the last 2 years and in the wake of SARS-CoV2 pandemic, a multitude of studies have increased our insight into these conditions. Although large-vessel and medium-vessel vasculitis are uncommon amongst children, they are a complex and multisystem with a constantly evolving landscape. Increasing numbers of reports from low-income and middle-income countries are shaping our understanding of the epidemiology of vasculitis in children. The influence of infectious disease and the microbiome are of particular interest in unravelling pathogenetic aspects. Improved understanding of the genetics and immunology offer opportunities for better diagnostic options and biomarkers of disease as well as targeted therapies.

Summary: In this review, we address recent findings in epidemiology, pathophysiology, clinical findings, bio-markers, imaging and treatment that have the potential to offer better management solutions for these uncommon conditions.

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儿童中、大血管炎。

综述的目的:这篇文章是对儿科大血管和中血管炎领域最新发现的最新检查。最近的发现:在过去的两年里，在SARS-CoV2大流行之后，大量的研究增加了我们对这些疾病的了解。虽然大血管和中血管炎在儿童中并不常见，但它们是一个复杂的多系统，具有不断演变的景观。来自低收入和中等收入国家的越来越多的报告正在影响我们对儿童血管炎流行病学的理解。传染病和微生物组的影响在揭示发病方面具有特别的意义。对遗传学和免疫学的进一步了解为更好的诊断选择和疾病的生物标志物以及靶向治疗提供了机会。摘要:在这篇综述中，我们讨论了流行病学、病理生理学、临床表现、生物标志物、成像和治疗方面的最新发现，这些发现有可能为这些罕见疾病提供更好的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in rheumatology 医学-风湿病学

CiteScore

9.70

自引率

2.00%

发文量

审稿时长

6-12 weeks

期刊介绍： A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.

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