Dynamic of irisin secretion change after moderate-intensity chronic physical exercise on obese female.

Q3 Pharmacology, Toxicology and Pharmaceutics Journal of Basic and Clinical Physiology and Pharmacology Pub Date : 2023-07-01 DOI:10.1515/jbcpp-2023-0041
Desiana Merawati, Sugiharto, Hendra Susanto, Ahmad Taufiq, Adi Pranoto, Dessy Amelia, Purwo Sri Rejeki
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引用次数: 2

Abstract

Objectives: Exercise is one of the beneficial mediators for the regulation and prevention of obesity through the role of irisin, so it potentially enhances metabolism health. This study aims to investigate the dynamic of irisin secrecy change after chronic exercise in obese females.

Methods: Thirty-one female adolescents aged 20-22 years enrolled in the study and were given interventions aerobic, resistance, and a combination of aerobic and resistance training. The exercises were performed at moderate-intensity, for 35-40 min per session, and three times a week for four weeks. The measurement of irisin level, IGF-1 level, and bio-anthropometry was carried out before and after the four weeks of exercise. The bio-anthropometry measurement was carried out using seca mBCA 514, while the measurement of insulin-like growth factor 1 (IGF-1) and irisin was completed using an enzyme-linked immunosorbent assay (ELISA). The obtained data were analyzed using a one-way ANOVA test with 5 % significance.

Results: Our results indicated higher dynamic of irisin and IGF-1 increases in the group with a combination of aerobic and resistance training exercises than the other two groups with a different exercise. Further, we also observed different dynamics of irisin and IGF-1 level increase (p<0.05). Besides, the irisin was also correlated with the IGF-1 and bio-anthropometric parameters (p<0.05).

Conclusions: The combination of aerobic and resistance training exercises is considered as the alternative for enhancing the dynamic of irisin and IGF-1 increase. Thus, it can be used to prevent and regulate obesity.

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肥胖女性慢性中等强度体育锻炼后鸢尾素分泌动态变化。
目的:运动是通过鸢尾素的作用调节和预防肥胖的有益介质之一,因此它有可能促进代谢健康。本研究旨在探讨肥胖女性慢性运动后鸢尾素的动态变化。方法:31名年龄在20-22岁的女性青少年被纳入研究,并给予有氧、阻力和有氧与阻力相结合的干预训练。运动以中等强度进行,每次35-40 分钟,每周三次,持续四周。在运动前后进行鸢尾素水平、IGF-1水平和生物人体测量。使用seca mBCA 514进行生物人体测量,使用酶联免疫吸附试验(ELISA)完成胰岛素样生长因子1 (IGF-1)和鸢尾素的测量。所得资料采用单因素方差分析,显著性为5 %。结果:我们的研究结果表明,与其他两组不同的运动相比,有氧和阻力训练相结合的组鸢尾素和IGF-1的动态增长更高。此外,我们还观察到鸢尾素和IGF-1水平升高的不同动态(p结论:有氧和阻力训练相结合被认为是提高鸢尾素和IGF-1升高动态的替代方案。因此,它可以用来预防和调节肥胖。
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来源期刊
Journal of Basic and Clinical Physiology and Pharmacology
Journal of Basic and Clinical Physiology and Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.90
自引率
0.00%
发文量
53
期刊介绍: The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including brain research; cardiovascular-pulmonary interactions; exercise; thermal control; haematology; immune response; inflammation; metabolism; oxidative stress; and phytotherapy. As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes. Topics: Behavior and Neuroprotection, Reproduction, Genotoxicity and Cytotoxicity, Vascular Conditions, Cardiovascular Function, Cardiovascular-Pulmonary Interactions, Oxidative Stress, Metabolism, Immune Response, Hematological Profile, Inflammation, Infection, Phytotherapy.
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