{"title":"[The current status and optimization strategies of CAR-T cell therapy in hematological malignancies].","authors":"F C Wang, P Li, A B Liang","doi":"10.3760/cma.j.cn112138-20230410-00191","DOIUrl":null,"url":null,"abstract":"嵌合抗原受体T细胞（CAR-T细胞）疗法已成为治疗某些血液系统恶性肿瘤包括白血病、淋巴瘤和多发性骨髓瘤很有前途的一种治疗方式。然而耐药和疾病复发的出现，也给CAR-T细胞疗法提出了挑战。本文总结了目前CAR-T细胞疗法在中国的审批情况、提高CAR-T治疗效果方面的研究进展以及CAR-T细胞治疗遇到的挑战和未来方向，以期能为后续CAR-T治疗方案的优化提供借鉴。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 6","pages":"581-586"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhonghua nei ke za zhi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/cma.j.cn112138-20230410-00191","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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