Decrypting biological hallmarks of aging in people with HIV.

IF 4.5 3区 医学 Q2 IMMUNOLOGY Current Opinion in HIV and AIDS Pub Date : 2023-09-01 DOI:10.1097/COH.0000000000000810
Thomas A Premeaux, Lishomwa C Ndhlovu
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Abstract

Purpose of review: HIV infection adds further complexity to the heterogenous process of aging. In this focused review, we examine and discuss recent advances to better elucidate mechanisms of biological aging perturbed and accelerated in the context of HIV, particularly among those with viral suppression through the benefits of antiretroviral therapy (ART). New hypotheses from these studies are poised to provide an improved understanding of multifaceted pathways that converge and likely form the basis for effective interventions toward successful aging.

Recent findings: Evidence to date suggests multiple mechanisms of biological aging impact people living with HIV (PLWH). Recent literature delves and expands on how epigenetic alterations, telomere attrition, mitochondrial perturbations, and intercellular communications may underpin accelerated or accentuated aging phenotypes and the disproportionate prevalence of age-related complications among PLWH. Although most hallmarks of aging are likely exacerbated in the setting of HIV, ongoing research efforts are providing new insight on the collective impact these conserved pathways may have in the aging disease processes.

Summary: New knowledge on underlying molecular disease mechanisms impacting people aging with HIV are reviewed. Also examined are studies that may facilitate the development and implementation of effective therapeutics and guidance on improving geriatric HIV clinical care.

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破解艾滋病毒感染者衰老的生物学特征。
综述目的:HIV感染使衰老的异质性过程更加复杂。在这篇重点综述中,我们检查和讨论了最近的进展,以更好地阐明在艾滋病毒背景下生物衰老的紊乱和加速机制,特别是在那些通过抗逆转录病毒治疗(ART)抑制病毒的患者中。来自这些研究的新假设准备提供对多方面途径的更好理解,这些途径汇聚在一起,可能形成有效干预成功衰老的基础。最新发现:迄今为止的证据表明,生物衰老影响艾滋病毒感染者(PLWH)的多种机制。最近的文献深入并扩展了表观遗传改变,端粒磨损,线粒体扰动和细胞间通讯如何支持加速或加剧衰老表型以及PLWH中年龄相关并发症的不成比例流行。尽管大多数衰老标志可能在HIV环境下加剧,但正在进行的研究工作正在为这些保守途径在衰老疾病过程中可能产生的集体影响提供新的见解。综述了影响HIV感染者衰老的潜在分子疾病机制的新知识。还审查了可能促进制定和实施有效治疗方法的研究,以及改善老年艾滋病毒临床护理的指导。
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来源期刊
Current Opinion in HIV and AIDS
Current Opinion in HIV and AIDS IMMUNOLOGY-INFECTIOUS DISEASES
CiteScore
7.40
自引率
7.30%
发文量
115
审稿时长
6-12 weeks
期刊介绍: Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in HIV and AIDS features hand-picked review articles from our team of expert editors. With six disciplines published across the year – including HIV and ageing, a HIV vaccine, and epidemiology – every issue also contains annotated reference detailing the merits of the most important papers.
期刊最新文献
Recent data on the role of antiretroviral therapy in weight gain and obesity in persons living with HIV. Anticipating HIV viral escape - resistance to active and passive immunization. Accelerating HIV vaccine development through meaningful engagement of local scientists and communities. Guiding HIV-1 vaccine development with preclinical nonhuman primate research. Discovery medicine - the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine.
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