Developing Phage Therapy That Overcomes the Evolution of Bacterial Resistance.

IF 8.1 1区 医学 Q1 VIROLOGY Annual Review of Virology Pub Date : 2023-09-29 Epub Date: 2023-06-02 DOI:10.1146/annurev-virology-012423-110530
Agnès Oromí-Bosch, Jyot D Antani, Paul E Turner
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引用次数: 4

Abstract

The global rise of antibiotic resistance in bacterial pathogens and the waning efficacy of antibiotics urge consideration of alternative antimicrobial strategies. Phage therapy is a classic approach where bacteriophages (bacteria-specific viruses) are used against bacterial infections, with many recent successes in personalized medicine treatment of intractable infections. However, a perpetual challenge for developing generalized phage therapy is the expectation that viruses will exert selection for target bacteria to deploy defenses against virus attack, causing evolution of phage resistance during patient treatment. Here we review the two main complementary strategies for mitigating bacterial resistance in phage therapy: minimizing the ability for bacterial populations to evolve phage resistance and driving (steering) evolution of phage-resistant bacteria toward clinically favorable outcomes. We discuss future research directions that might further address the phage-resistance problem, to foster widespread development and deployment of therapeutic phage strategies that outsmart evolved bacterial resistance in clinical settings. Expected final online publication date for the Annual Review of Virology, Volume 10 is September 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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开发噬菌体疗法,克服细菌耐药性的进化。
细菌病原体抗生素耐药性的全球上升和抗生素疗效的下降促使人们考虑替代性的抗菌策略。噬菌体治疗是一种经典的方法,噬菌体(细菌特异性病毒)用于对抗细菌感染,最近在顽固性感染的个性化药物治疗方面取得了许多成功。然而,开发通用噬菌体疗法的一个永恒挑战是,期望病毒对目标细菌进行选择,以部署防御病毒攻击的能力,从而在患者治疗过程中导致噬菌体耐药性的进化。在这里,我们回顾了在噬菌体治疗中减轻细菌耐药性的两种主要互补策略:最大限度地降低细菌群体进化噬菌体耐药性的能力,并推动(引导)噬菌体耐药性细菌进化到临床有利的结果。我们讨论了未来可能进一步解决噬菌体耐药性问题的研究方向,以促进治疗性噬菌体策略的广泛开发和部署,从而在临床环境中智胜进化的细菌耐药性。
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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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