Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration

IF 18.6 1区 医学 Q1 OPHTHALMOLOGY Progress in Retinal and Eye Research Pub Date : 2023-01-01 DOI:10.1016/j.preteyeres.2022.101114
David Križaj , Soenke Cordeiro , Olaf Strauß
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引用次数: 12

Abstract

Transient receptor potential (TRP) channels are a widely expressed family of 28 evolutionarily conserved cationic ion channels that operate as primary detectors of chemical and physical stimuli and secondary effectors of metabotropic and ionotropic receptors. In vertebrates, the channels are grouped into six related families: TRPC, TRPV, TRPM, TRPA, TRPML, and TRPP. As sensory transducers, TRP channels are ubiquitously expressed across the body and the CNS, mediating critical functions in mechanosensation, nociception, chemosensing, thermosensing, and phototransduction. This article surveys current knowledge about the expression and function of the TRP family in vertebrate retinas, which, while dedicated to transduction and transmission of visual information, are highly susceptible to non-visual stimuli. Every retinal cell expresses multiple TRP subunits, with recent evidence establishing their critical roles in paradigmatic aspects of vertebrate vision that include TRPM1-dependent transduction of ON bipolar signaling, TRPC6/7-mediated ganglion cell phototransduction, TRP/TRPL phototransduction in Drosophila and TRPV4-dependent osmoregulation, mechanotransduction, and regulation of inner and outer blood-retina barriers. TRP channels tune light-dependent and independent functions of retinal circuits by modulating the intracellular concentration of the 2nd messenger calcium, with emerging evidence implicating specific subunits in the pathogenesis of debilitating diseases such as glaucoma, ocular trauma, diabetic retinopathy, and ischemia. Elucidation of TRP channel involvement in retinal biology will yield rewards in terms of fundamental understanding of vertebrate vision and therapeutic targeting to treat diseases caused by channel dysfunction or over-activation.

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视网膜TRP通道:视网膜稳态和多模态整合的细胞类型特异性调节因子
瞬时受体电位(TRP)通道是一个由28个进化上保守的阳离子离子通道组成的广泛表达的家族,它们作为化学和物理刺激的主要检测器以及代谢型和离子型受体的次要效应器。脊椎动物的通道分为六个相关家族:TRPC、TRPV、TRPM、TRPA、TRPML和TRPP。作为感觉传感器,TRP通道在全身和中枢神经系统中普遍表达,介导机械感觉、伤害感受、化学感受、热感和光转导的关键功能。本文综述了目前关于TRP家族在脊椎动物视网膜中的表达和功能的知识,脊椎动物视网膜虽然致力于视觉信息的转导和传递,但对非视觉刺激高度敏感。每个视网膜细胞都表达多个TRP亚基,最近的证据证明了它们在脊椎动物视觉的典型方面的关键作用,包括TRPM1依赖性ON双极信号传导、TRPC6/7介导的神经节细胞光转导、果蝇的TRP/TRPL光转导和TRPV4依赖性渗透调节、机械转导,以及视网膜内外血屏障的调节。TRP通道通过调节第二信使钙的细胞内浓度来调节视网膜回路的光依赖性和非依赖性功能,新出现的证据表明,特定亚基参与了青光眼、眼外伤、糖尿病视网膜病变和缺血等衰弱性疾病的发病机制。阐明TRP通道参与视网膜生物学将在对脊椎动物视觉的基本理解和治疗由通道功能障碍或过度激活引起的疾病的靶向性方面产生回报。
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来源期刊
CiteScore
34.10
自引率
5.10%
发文量
78
期刊介绍: Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists. The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.
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