Is physical performance affected by non-steroidal anti-inflammatory drugs use? A systematic review and meta-analysis.

IF 1.9 4区医学 Q2 ORTHOPEDICS Physician and Sportsmedicine Pub Date : 2024-06-01 Epub Date: 2023-06-08 DOI:10.1080/00913847.2023.2220439

Gabriel Moraes de Oliveira, Fernando Augusto Barcelos Andrade, André Bahia Pereira, Rodrigo Silva Viza, Henrique Fernandes Gerspacher, Mateus da Costa Monteiro, Helton Oliveira Campos, Lucas Rios Drummond, Laura Hora Rios Leite, Cândido Celso Coimbra

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Abstract

Objective: This systematic review and meta-analysis aim to analyze the effects of ingesting non-steroidal anti-inflammatory drugs (NSAIDs) on physical performance, muscle strength, and muscle damage in three different moments: immediately, 24 and 48 h after resistance exercise practice.

Methods: Relevant studies were researched in three databases (PubMed, Web of Science and SPORTDiscus) in April 2023. After excluding duplicates, the decision to include or exclude studies was made by two independent investigators in the following steps: (I) the study title; (II) the study abstract; and (III) the complete study manuscript. The following characteristics were recorded: (I) first author, (II) year of publication, (III) sample size, (IV) method of NSAIDs administration, (V) exercise protocol, and (VI) analyzed variable results. The studies selected were divided into trials that evaluated the effects of NSAIDs ingestion on performance indices of resistance exercise, endurance exercise and resistance training.

Results: The meta-analysis, based only on resistance exercises, revealed that both performance and muscle strength were similar between placebo or NSAID treatment immediately and 24 h after resistance exercise practice. An ergolytic effect was found 48 hours after resistance exercise (mean effect size (ES) = -0.42; 95% CI: -0.71, -0.12; p = 0.132), as well as reduced muscle strength (ES = -0.50; 95% CI: -0.83, -0.16; p = 0.072). Additionally, NSAID use did not prevent muscle waste as seen by the unchanged CK plasma concentration at all timetables.

Conclusion: The data of the present meta-analysis indicate that NSAID use is ineffective in improving resistance performance and muscle strength, as well as exercise recovery. When considering the practical application of using NSAIDs to improve exercise capacity and strength gains, the present data supports that consumption of analgesic drugs as an endurance performance enhancer or as a muscle anabolic must not be recommended.

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使用非甾体抗炎药会影响体能吗？系统回顾和荟萃分析。

研究目的本系统综述和荟萃分析旨在分析在阻力运动练习后立即、24 小时和 48 小时这三个不同时间摄入非甾体抗炎药（NSAIDs）对体能表现、肌肉力量和肌肉损伤的影响：方法：2023 年 4 月在三个数据库（PubMed、Web of Science 和 SPORTDiscus）中对相关研究进行了研究。在排除重复研究后，由两名独立调查人员按照以下步骤决定是否纳入研究：(I) 研究题目；(II) 研究摘要；(III) 完整的研究手稿。记录以下特征：(I) 第一作者；(II) 发表年份；(III) 样本大小；(IV) 给予非甾体抗炎药的方法；(V) 运动方案；(VI) 分析变量结果。所选研究分为评估摄入非甾体抗炎药对阻力运动、耐力运动和阻力训练表现指数影响的试验：荟萃分析仅基于阻力练习，结果显示，在阻力练习后 24 小时内服用安慰剂或服用非甾体抗炎药，两者的运动表现和肌肉力量相似。在阻力运动后 48 小时发现了溶解作用（平均效应大小 (ES) = -0.42；95% CI：-0.71, -0.12；p = 0.132），以及肌肉力量下降（ES = -0.50；95% CI：-0.83, -0.16；p = 0.072）。此外，使用非甾体抗炎药并不能防止肌肉废用性，因为在所有时间表中，CK 血浆浓度均保持不变：本荟萃分析的数据表明，使用非甾体抗炎药对提高阻力表现和肌肉力量以及运动恢复无效。在考虑使用非甾体抗炎药来提高运动能力和增强力量的实际应用时，本数据支持不推荐将镇痛药用作耐力表现增强剂或肌肉同化剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physician and Sportsmedicine PRIMARY HEALTH CARE-ORTHOPEDICS

CiteScore

4.90

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： The Physician and Sportsmedicine is a peer-reviewed, clinically oriented publication for primary care physicians. We examine the latest drug discoveries to advance treatment and recovery, and take into account the medical aspects of exercise therapy for a given condition. We cover the latest primary care-focused treatments serving the needs of our active patient population, and assess the limits these treatments govern in stabilization and recovery. The Physician and Sportsmedicine is a peer-to-peer method of communicating the latest research to aid primary care physicians’ advancement in methods of care and treatment. We routinely cover such topics as: managing chronic disease, surgical techniques in preventing and managing injuries, the latest advancements in treatments for helping patients lose weight, and related exercise and nutrition topics that can impact the patient during recovery and modification.