Inhaled Volatile Molecules-Responsive TRP Channels as Non-Olfactory Receptors.

IF 3 3区 医学 Q2 PHARMACOLOGY & PHARMACY Biomolecules & Therapeutics Pub Date : 2024-03-01 Epub Date: 2023-08-08 DOI:10.4062/biomolther.2023.118
Hyungsup Kim, Minwoo Kim, Yongwoo Jang
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Abstract

Generally, odorant molecules are detected by olfactory receptors, which are specialized chemoreceptors expressed in olfactory neurons. Besides odorant molecules, certain volatile molecules can be inhaled through the respiratory tract, often leading to pathophysiological changes in the body. These inhaled molecules mediate cellular signaling through the activation of the Ca2+-permeable transient receptor potential (TRP) channels in peripheral tissues. This review provides a comprehensive overview of TRP channels that are involved in the detection and response to volatile molecules, including hazardous substances, anesthetics, plant-derived compounds, and pheromones. The review aims to shed light on the biological mechanisms underlying the sensing of inhaled volatile molecules. Therefore, this review will contribute to a better understanding of the roles of TRP channels in the response to inhaled molecules, providing insights into their implications for human health and disease.

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作为非嗅觉受体的吸入挥发性分子反应性 TRP 通道
一般来说,气味分子是由嗅觉受体检测到的,嗅觉受体是在嗅觉神经元中表达的特化化学感受器。除气味分子外,某些挥发性分子也可通过呼吸道被吸入人体,从而导致人体发生病理生理变化。这些吸入的分子通过激活外周组织的钙离子渗透性瞬时受体电位(TRP)通道来介导细胞信号传导。本综述全面概述了参与检测和响应挥发性分子(包括有害物质、麻醉剂、植物源化合物和信息素)的 TRP 通道。综述旨在阐明吸入挥发性分子感知的生物机制。因此,本综述将有助于更好地理解 TRP 通道在对吸入分子的反应中的作用,并深入探讨其对人类健康和疾病的影响。
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来源期刊
CiteScore
6.60
自引率
8.10%
发文量
72
审稿时长
6-12 weeks
期刊介绍: Biomolecules & Therapeutics (Biomolecules & Therapeutics) (Print ISSN 1976-9148, Online ISSN 2005-4483) is an international, peer-reviewed, open access journal that covers pharmacological and toxicological fields related to bioactive molecules and therapeutics. It was launched in 1993 as "The Journal of Applied Pharmacology (ISSN 1225-6110)", and renamed "Biomolecules & Therapeutics" (Biomol Ther: abbreviated form) in 2008 (Volume 16, No. 1). It is published bimonthly in January, March, May, July, September and November. All manuscripts should be creative, informative, and contribute to the development of new drugs. Articles in the following categories are published: review articles and research articles.
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