Electrophysiological effects of hyperbaric oxygen treatment on the healthy retina.

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY Cutaneous and Ocular Toxicology Pub Date : 2023-09-01 DOI:10.1080/15569527.2023.2217250
Nur Demir, Belma Kayhan, Selin Gamze Sumen, Murat Sonmez, Nejla Tukenmez Dikmen
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Abstract

Purpose: The study aimed to investigate the electrophysiological effects of hyperbaric oxygen treatment (HBOT) on the retina after ten sessions in healthy eyes.

Methods: This prospective, interventional study evaluated forty eyes of twenty patients who were treated with HBOT of ten sessions with the diagnosis of an extraocular health problem. All patients underwent a complete ophthalmologic examination, including assessments of best-corrected visual acuity (BCVA), slit-lamp and pupil-dilated fundus examinations, full-field electroretinography (ffERG) measurements before and after HBOT within 24 h of the 10th session. The ffERG was recorded according to the International Society for Clinical Electrophysiology of Vision protocol using the RETI-port system.

Results: The mean age of patients was 40.5 years ranging from 20 to 59 years. Thirteen patients were administered HBOT for avascular necrosis, six patients for sudden hearing loss, and one patient for chronic osteomyelitis of the vertebra. BCVA acuity was 20/20 in all eyes. The mean spherical refractive was 0.56 dioptre (D), and the mean cylindrical refractive error was 0.75 D. Dark-adapted b-wave amplitude in 3.0 ERG was the only variable for the b-wave that showed a statistically significant decrease (p = 0.017). The amplitude of the a-waves in dark-adapted 10.0 ERG and light-adapted 3.0 ERG reduced significantly (p = 0.024, p = 0.025). The amplitude of N 1-P 1 in light-adapted 30 Hz Flicker ERG also demonstrated a statistically significant decrease (p = 0.011). Implicit times did not differ significantly in any of the ffERG data (p > 0.05).

Conclusions: HBOT caused the deterioration of a-wave and b-wave amplitudes in ffERG after ten treatment sessions. The results showed that photoreceptors were adversely affected in the short term after HBOT treatment.

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高压氧治疗对健康视网膜的电生理影响。
目的:观察健康眼高压氧治疗(HBOT) 10次后对视网膜电生理的影响。方法:这项前瞻性、介入性研究评估了20名诊断为眼外健康问题的患者的40只眼睛,这些患者接受了10次HBOT治疗。所有患者均接受了完整的眼科检查,包括最佳矫正视力(BCVA)评估、裂隙灯和瞳孔扩张眼底检查、HBOT前后24小时内的全视野视网膜电图(ffERG)测量。ffERG按照国际临床视觉电生理学会使用rti -port系统记录。结果:患者平均年龄40.5岁,年龄范围20 ~ 59岁。13例缺血性坏死患者接受HBOT治疗,6例突发性听力损失患者接受HBOT治疗,1例椎体慢性骨髓炎患者接受HBOT治疗。双眼BCVA视力均为20/20。平均球面屈光度为0.56屈光度(D),平均圆柱屈光度为0.75 D。3.0 ERG的暗适应b波振幅是b波唯一有统计学意义下降的变量(p = 0.017)。暗适应10.0 ERG和光适应3.0 ERG的a波振幅显著降低(p = 0.024, p = 0.025)。光适应30 Hz闪烁ERG中n1 - p1的振幅也有统计学意义的降低(p = 0.011)。隐式时间在所有ffERG数据中无显著差异(p > 0.05)。结论:HBOT治疗10个疗程后,引起了ffERG a波和b波振幅的恶化。结果表明,HBOT处理后,短期内光感受器受到不良影响。
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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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