Compare of optic coherence tomography parameters in recreational synthetic tetrahydrocannabinol use and healthy control.

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY Cutaneous and Ocular Toxicology Pub Date : 2023-09-01 DOI:10.1080/15569527.2023.2234042
Mehmet Tahir Eski, Kuddusi Teberik, Sezer Taha, Bora Büken, Feruza Turan Sönmez
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Abstract

Purpose: To evaluate retinal thickness (RT), retinal nerve fiber layer thickness (RNFLT), and choroidal thickness (CT) changes in synthetic cannabinoid (SC) users.

Methods: This prospective study evaluated the RT, RNFLT, and CT values of 56 SC users and 58 healthy controls. The individuals using SCs were referred to us by our hospital's forensic medicine department. Retinal and choroidal images were obtained using spectral-domain optical coherence tomography (OCT). Measurements (one subfoveal, three temporals, three nasal) were taken at 500 μm intervals up to 1500 μm using the caliper system. Only the right eye was used for subsequent analysis.

Results: Mean ages were 27.7 ± 5.7 years in the SC-user group and 25.4 ± 6.7 in the control group. Subfoveal Global RNFLT was in the SCs group 102.3 ± 10.5 μm and 105.6 ± 20.2 μm in the control group (p = 0.271). Subfoveal CT was in the SC group mean of 316.1 ± 100.2 μm and in the control group mean 346.4 ± 81.8 μm (p = 0.065). RT, T500 (283.3 ± 36.7 μm, 296.6 ± 20.5 μm, p = 0.011) and N1500 (355.1 ± 14.3 μm, 349.3 ± 18.1 μm, p = 0.049) were significantly higher in the SC group than in the control group, respectively.

Conclusion: Analysis of OCT findings of individuals who had been using SC for more than one year revealed no statistically significant difference between RNFLT and CT, although N1500 was significantly higher in RT. Further studies in the field of OCT are important to explore the pathology of SC.

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娱乐性合成四氢大麻酚使用与健康对照的光学相干断层成像参数比较。
目的:评价合成大麻素(SC)使用者视网膜厚度(RT)、视网膜神经纤维层厚度(RNFLT)和脉络膜厚度(CT)的变化。方法:本前瞻性研究评估了56例SC使用者和58例健康对照者的RT、RNFLT和CT值。使用SCs的人是由我们医院的法医学部门转介给我们的。使用光谱域光学相干断层扫描(OCT)获得视网膜和脉络膜图像。使用卡尺系统以500 μm至1500 μm的间隔进行测量(一次中央凹下,三个颞部,三个鼻部)。后续分析只使用右眼。结果:sc使用者组平均年龄27.7±5.7岁,对照组平均年龄25.4±6.7岁。sc组中央凹下Global RNFLT为102.3±10.5 μm,对照组为105.6±20.2 μm (p = 0.271)。SC组中央凹下CT平均值为316.1±100.2 μm,对照组平均值为346.4±81.8 μm (p = 0.065)。SC组RT、T500(283.3±36.7 μm, 296.6±20.5 μm, p = 0.011)和N1500(355.1±14.3 μm, 349.3±18.1 μm, p = 0.049)均显著高于对照组。结论:对使用SC 1年以上患者的OCT结果分析显示,RNFLT与CT无统计学差异,但rt的N1500明显高于CT。进一步开展OCT领域的研究对探讨SC的病理有重要意义。
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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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