IL-10 (-819C/T), TNFA (-30G/A) and ENOS (-786T/C) Polymorphisms Modulating the Outcome Related to Mental Disorders in Crack Addicted Users.

Pub Date : 2022-01-01 DOI:10.2174/17450179-v18-e2201140

Ana Caroline Melo Dos Santos, Barbara Rayssa Correia Dos Santos, Bruna Brandão Dos Santos, Edilson Leite de Moura, Abel Barbosa Lira Neto, Aline Cristine Pereira E Silva, Karol Fireman de Farias, Verônica de Medeiros Alves, Antônio Egídio Nardi, Elaine Virgínia Martins de Souza Figueiredo

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引用次数: 1

Abstract

Background: Cocaine/crack use affects immune system molecules and development of mental disorders has been identified.

Objective: To investigate the relationship of polymorphisms in the TNFA (-308G/A), IL-10 (-819C/T) and ENOS (-786T/C) genes with mental disorders in cocaine and crack users.

Methods: A case-control study was carried out, which included 107 cocaine and crack users and 115 controls who never used healthy cocaine and crack. The SNPs in the TNFA (-308G/A), IL-10 (-819C/T) and ENOS (-786T/C) genes were genotyped by real time PCR.

Results: As for the individuals included in this study, the average age of 31.4 years (± 8.59). We identified that the G/A genotype to TNFA (-308) (OR = 0.24; p = 0.03) and the A allele (OR = 0.30; p = 0.03) were associated with reduced risk for dysthymic disorder. The T allele of the IL-10 (-819) polymorphism was associated with decreased risk of developing panic disorder (OR = 0.44; p = 0.01), while the C allele was correlated with an increased risk for alcohol dependence (OR = 1.97; p = 0.04), alcohol abuse (OR = 1.81; p = 0.04) and psychotic syndrome (OR = 2.23; p = 0.01). C/C genotype was correlated with increased chances of developing current psychotic syndrome (OR = 4.23; p = 0.01).

Conclusion: Our results suggest that genetic polymorphisms promote susceptibility or promote protection for clinical phenotypes of psychiatric comorbidities in cocaine and crack users and be considered as good prognostic markers.

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IL-10 (-819C/T)、TNFA (-30G/A)和ENOS (-786T/C)多态性调节可卡因成瘾者精神障碍相关预后

背景:可卡因/快克使用影响免疫系统分子和精神障碍的发展已被确定。目的:探讨TNFA (-308G/A)、IL-10 (-819C/T)和ENOS (-786T/C)基因多态性与可卡因和快克吸毒者精神障碍的关系。方法:采用病例对照研究，纳入107例可卡因和快克使用者和115例未正常使用可卡因和快克的对照者。采用real - time PCR对TNFA (-308G/A)、IL-10 (-819C/T)和ENOS (-786T/C)基因的snp进行分型。结果:入组个体平均年龄31.4岁(±8.59岁)。我们发现G/A基因型对TNFA (-308) (OR = 0.24;p = 0.03)和A等位基因(OR = 0.30;P = 0.03)与心境恶劣障碍风险降低相关。IL-10(-819)多态性的T等位基因与发生惊恐障碍的风险降低相关(OR = 0.44;p = 0.01)，而C等位基因与酒精依赖风险增加相关(OR = 1.97;p = 0.04)，酗酒(OR = 1.81;p = 0.04)和精神病综合征(OR = 2.23;P = 0.01)。C/C基因型与当前精神病综合征发生几率增加相关(OR = 4.23;P = 0.01)。结论:我们的研究结果表明，遗传多态性促进了可卡因和快克吸毒者精神合并症的易感性或促进了临床表型的保护，并被认为是良好的预后标志物。

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