Physiology & Behavior最新文献

The effect of blue light on cognitive function at workplaces: A systematic review 蓝光对工作场所认知功能的影响：系统综述：蓝光与认知功能。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-02-01 DOI: 10.1016/j.physbeh.2024.114758

Soheyla Ahmadi Charkhabi , Zahra Sharifi , Raziyeh Janizadeh , Mohammad Rahdar , Reza Kazemi

Aim

Due to the widespread use of artificial lighting in modern workplaces, exposure to blue light is becoming increasingly common. Blue light, known for its shorter wavelength and higher energy, has been linked to both positive and negative effects on cognitive functions and well-being.

Objective

This systematic review explores the impact of blue light exposure on cognitive performance and sleep in various workplace settings.

Material and methods

This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Using predefined inclusion and exclusion criteria, the team searched three reputable databases (PubMed, Web of Science, and Scopus). Two authors independently screened the search results and the three other authors performed the data extraction and validation from the selected documents. The quality of the articles was assessed using the quality assessment checklist provided by The Joanna Briggs Institute (JBI).

Results

From an initial set of 63 articles, 29 documents met the inclusion criteria. The findings reveal that blue light, particularly at high color temperatures and intensities, enhances cognitive functions such as attention, alertness, and reaction time. However, its effects on memory and sleep were more variable. Exposure to blue-enriched light was consistently associated with improved workplace performance, although some studies reported a mixed or insignificant impact.

Conclusion

This review underscores the potential benefits of blue light in workplace settings, particularly for enhancing attention and reaction times. However, variations in study outcomes suggest the need for standardized lighting interventions and further research on its long-term cognitive impacts.

目的：由于人工照明在现代工作场所的广泛使用，暴露在蓝光下变得越来越普遍。蓝光以波长更短、能量更高而闻名，它对认知功能和健康既有积极的影响，也有消极的影响。目的：本系统综述探讨了不同工作环境下蓝光照射对认知表现和睡眠的影响。材料和方法：本系统评价遵循系统评价和荟萃分析的首选报告项目（PRISMA）指南。使用预定义的纳入和排除标准，研究小组搜索了三个著名的数据库（PubMed、Web of Science和Scopus）。两位作者独立筛选搜索结果，另外三位作者从选定的文档中进行数据提取和验证。使用乔安娜布里格斯研究所（JBI）提供的质量评估清单对文章的质量进行评估。结果：在最初的63篇文章中，29篇符合纳入标准。研究结果表明，蓝光，特别是高色温和高强度的蓝光，可以增强认知功能，如注意力、警觉性和反应时间。然而，它对记忆和睡眠的影响则更加多变。暴露在富含蓝光的光线下一直与改善工作表现有关，尽管一些研究报告的影响好坏参半或微不足道。结论：这篇综述强调了蓝光在工作场所的潜在好处，特别是在提高注意力和反应时间方面。然而，研究结果的差异表明，需要标准化的照明干预措施，并进一步研究其长期认知影响。

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引用次数: 0

Corrigendum to ‘Deep learning dives: Predicting anxiety in Zebrafish through novel tank assay analysis’ Physiology & Behavior (2024), 114696 深度学习潜水：通过新型水槽检测分析预测斑马鱼的焦虑"，《生理学与行为学》（2024 年），第 114696 期。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-02-01 DOI: 10.1016/j.physbeh.2024.114705

Anagha Muralidharan, Amrutha Swaminathan, Alwin Poulose

Abstract

摘要

引用次数: 0

Network structure of sleep quality and its bridging association with anhedonia in adolescent major depression disorder

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-31 DOI: 10.1016/j.physbeh.2025.114833

Xianyang Wang , Lei Ren , Xinxin Zhao , Yifan Shi , Jingwen Li , Wenjun Wu , Huan Yu , Runxin Lv , Nian Liu , Xiatong Wu , Hailong Dong , Guangchao Zhao , Huaning Wang , Min Cai

Background

Major depressive disorder (MDD) is a leading cause of disease burden in adolescents, with persistently rising prevalence. Anhedonia, core symptom of adolescent MDD, is associated with suicidality and poor clinical outcomes. Impaired sleep quality is proven to be a significant risk factor for adolescent MDD and potentially influence anhedonia symptoms. Understanding the interplay between sleep quality and anhedonia is crucial for early intervention and treatment.

Methods

This cross-sectional study recruited 200 drug-naïve adolescent MDD patients from Xijing Hospital. Depression, anhedonia and sleep quality were assessed during outpatient visits, using the Hamilton Depression Rating Scale, Snaith-Hamilton Pleasure Scale, and Pittsburgh Sleep Quality Index, respectively. Network analysis was applied to construct sleep quality network and its co-occurrence network with anhedonia. Centrality indices were computed to indicate central symptoms.

Results

Adolescent MDD patients exhibited moderate depression and anhedonia levels, and are heavily accompanied with sleep complaints. The sleep quality network identified “subjective sleep quality” as the most central factor, mainly due to prolonged “sleep latency” and shortened “sleep duration”. In the co-occurrence network, “sleep disturbances” had prominent bridging connection with anhedonia, suggesting its critical role in activating anhedonia symptoms.

Conclusions

Subjective sleep quality was the most central sleep complaints in adolescent MDD, while sleep disturbances were prominently associated with anhedonia. These findings underscore the importance of reducing sleep disturbances to alleviate anhedonia symptoms under clinical settings. Network analysis provides a nuanced understanding of the complex relationship of sleep quality and its association with anhedonia in adolescent MDD.

{"title":"Network structure of sleep quality and its bridging association with anhedonia in adolescent major depression disorder","authors":"Xianyang Wang , Lei Ren , Xinxin Zhao , Yifan Shi , Jingwen Li , Wenjun Wu , Huan Yu , Runxin Lv , Nian Liu , Xiatong Wu , Hailong Dong , Guangchao Zhao , Huaning Wang , Min Cai","doi":"10.1016/j.physbeh.2025.114833","DOIUrl":"10.1016/j.physbeh.2025.114833","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) is a leading cause of disease burden in adolescents, with persistently rising prevalence. Anhedonia, core symptom of adolescent MDD, is associated with suicidality and poor clinical outcomes. Impaired sleep quality is proven to be a significant risk factor for adolescent MDD and potentially influence anhedonia symptoms. Understanding the interplay between sleep quality and anhedonia is crucial for early intervention and treatment.</div></div><div><h3>Methods</h3><div>This cross-sectional study recruited 200 drug-naïve adolescent MDD patients from Xijing Hospital. Depression, anhedonia and sleep quality were assessed during outpatient visits, using the Hamilton Depression Rating Scale, Snaith-Hamilton Pleasure Scale, and Pittsburgh Sleep Quality Index, respectively. Network analysis was applied to construct sleep quality network and its co-occurrence network with anhedonia. Centrality indices were computed to indicate central symptoms.</div></div><div><h3>Results</h3><div>Adolescent MDD patients exhibited moderate depression and anhedonia levels, and are heavily accompanied with sleep complaints. The sleep quality network identified “subjective sleep quality” as the most central factor, mainly due to prolonged “sleep latency” and shortened “sleep duration”. In the co-occurrence network, “sleep disturbances” had prominent bridging connection with anhedonia, suggesting its critical role in activating anhedonia symptoms.</div></div><div><h3>Conclusions</h3><div>Subjective sleep quality was the most central sleep complaints in adolescent MDD, while sleep disturbances were prominently associated with anhedonia. These findings underscore the importance of reducing sleep disturbances to alleviate anhedonia symptoms under clinical settings. Network analysis provides a nuanced understanding of the complex relationship of sleep quality and its association with anhedonia in adolescent MDD.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"292 ","pages":"Article 114833"},"PeriodicalIF":2.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of co-ingesting rice and liquid on glycemic response and gastric emptying in healthy subjects

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-30 DOI: 10.1016/j.physbeh.2025.114837

Tetsuro Matsunaga , Tetsuya Adachi , Koichiro Yasuda

Postprandial glycemic response is closely associated with gastric emptying rate. However, the effects of combining carbohydrates with liquid on gastric emptying and glycemic response are complicated. Here, we investigated the effect of co-ingesting rice and liquid in different ways on gastric emptying and glycemic response in healthy subjects. We performed a randomized crossover study in 12 healthy females. Three types of test meal were prepared: 150 g white rice (rice), 150 g white rice served alongside 200 mL of green tea (rice + tea), and 150 g white rice with 100 mL green tea poured over and served alongside 100 mL green tea (blend). After eating the test meal, measurements of postprandial glucose were performed, and breath samples for gastric emptying evaluation using (1–¹³C)-labeled sodium acetate breath test were collected for 120 min. Consumption of rice with liquid (both “rice + tea” and “blend”) induced significantly higher postprandial glycemic responses, in addition to significantly higher gastric emptying rates, than eating rice only. There were significant positive correlations between gastric emptying rate and postprandial glucose response. Our findings demonstrated that compared with eating rice only, drinking liquid when eating rice causes an increase in postprandial blood glucose levels due to accelerated gastric emptying.

{"title":"The effect of co-ingesting rice and liquid on glycemic response and gastric emptying in healthy subjects","authors":"Tetsuro Matsunaga , Tetsuya Adachi , Koichiro Yasuda","doi":"10.1016/j.physbeh.2025.114837","DOIUrl":"10.1016/j.physbeh.2025.114837","url":null,"abstract":"<div><div>Postprandial glycemic response is closely associated with gastric emptying rate. However, the effects of combining carbohydrates with liquid on gastric emptying and glycemic response are complicated. Here, we investigated the effect of co-ingesting rice and liquid in different ways on gastric emptying and glycemic response in healthy subjects. We performed a randomized crossover study in 12 healthy females. Three types of test meal were prepared: 150 g white rice (rice), 150 g white rice served alongside 200 mL of green tea (rice + tea), and 150 g white rice with 100 mL green tea poured over and served alongside 100 mL green tea (blend). After eating the test meal, measurements of postprandial glucose were performed, and breath samples for gastric emptying evaluation using (1–<sup>13</sup>C)-labeled sodium acetate breath test were collected for 120 min. Consumption of rice with liquid (both “rice + tea” and “blend”) induced significantly higher postprandial glycemic responses, in addition to significantly higher gastric emptying rates, than eating rice only. There were significant positive correlations between gastric emptying rate and postprandial glucose response. Our findings demonstrated that compared with eating rice only, drinking liquid when eating rice causes an increase in postprandial blood glucose levels due to accelerated gastric emptying.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"292 ","pages":"Article 114837"},"PeriodicalIF":2.4,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tachykinin-1-expressing parasubthalamic nucleus neurons are necessary for odorant-induced appetite suppression.

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-30 DOI: 10.1016/j.physbeh.2025.114836

Zoe E Kaegi, Matthew E Carter

Odorants play a critical role in regulating feeding behavior by signaling potential threats or food sources in the environment. However, the neural mechanisms by which odorants affect feeding are not well understood. Tachykinin-1-expressing neurons in the parasubthalamic nucleus (PSTN^Tac1 neurons) are critical for reducing food intake in response to internal appetite-suppressing hormones, gastric distension, and external cues that signal danger. Therefore, we tested the hypothesis that activity in these neurons is modulated by exposure to aversive, attractive, and neutral odorants. Using fiber photometry in mice, we found that PSTN^Tac1 neurons increase activity in response to the aversive predator odorants 2-methyl-2-thiazoline (2MT) and 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), but not to neutral or attractive odorants. This activation correlates with a reduction in food intake and an increase in the latency to initiate feeding. Furthermore, chemogenetic inhibition of PSTN^Tac1 neurons blocks the suppression of feeding caused by 2MT and TMT. These findings highlight the specificity of PSTN^Tac1 neurons in processing aversive olfactory signals and their critical role in integrating external threat cues with internal signals that regulate appetite.

{"title":"Tachykinin-1-expressing parasubthalamic nucleus neurons are necessary for odorant-induced appetite suppression.","authors":"Zoe E Kaegi, Matthew E Carter","doi":"10.1016/j.physbeh.2025.114836","DOIUrl":"https://doi.org/10.1016/j.physbeh.2025.114836","url":null,"abstract":"<p><p>Odorants play a critical role in regulating feeding behavior by signaling potential threats or food sources in the environment. However, the neural mechanisms by which odorants affect feeding are not well understood. Tachykinin-1-expressing neurons in the parasubthalamic nucleus (PSTN<sup>Tac1</sup> neurons) are critical for reducing food intake in response to internal appetite-suppressing hormones, gastric distension, and external cues that signal danger. Therefore, we tested the hypothesis that activity in these neurons is modulated by exposure to aversive, attractive, and neutral odorants. Using fiber photometry in mice, we found that PSTN<sup>Tac1</sup> neurons increase activity in response to the aversive predator odorants 2-methyl-2-thiazoline (2MT) and 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), but not to neutral or attractive odorants. This activation correlates with a reduction in food intake and an increase in the latency to initiate feeding. Furthermore, chemogenetic inhibition of PSTN<sup>Tac1</sup> neurons blocks the suppression of feeding caused by 2MT and TMT. These findings highlight the specificity of PSTN<sup>Tac1</sup> neurons in processing aversive olfactory signals and their critical role in integrating external threat cues with internal signals that regulate appetite.</p>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":" ","pages":"114836"},"PeriodicalIF":2.4,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding local thermal comfort and physiological responses in older people under uniform thermal environments

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-28 DOI: 10.1016/j.physbeh.2025.114832

Yin Tang , Hang Yu , Xianzhun Zhong , Kege Zhang , Huice Mao , Jing Geng , Meng Wang

The ageing population has increased the attention on care services for older people, particularly concerning their health and thermal comfort. However, most existing studies focus on the overall thermal comfort of older people, with insufficient research into their local thermal needs for different body parts, impeding precise thermal adjustments and optimal thermal satisfaction. This study investigated the local thermal comfort and skin temperature of older people under various environmental conditions. The results reveal significant variations in local thermal perceptions across body parts in older people under non-neutral thermal conditions. When wearing standard clothing (long-sleeved shirt and trousers) in cool environments, the back was the coldest part, followed by the lower body. In warm environments, the back, head, and chest exhibited higher thermal sensations. Weighting factors quantifying the influence of local thermal sensations on overall thermal sensation were calculated, identifying the head and back as key regions in warm conditions, and the back, arms, and legs in cool conditions. Local skin temperature also varied significantly across the body, with the head and trunk exhibiting higher temperatures and showing less fluctuation in response to environmental changes compared to the limbs. Furthermore, regression models between local thermal sensation and skin temperature were developed. Compared to the results from young people, older subjects showed significantly smaller variations in local thermal sensations across the body, along with significantly differences in local skin temperatures. These findings highlight the importance of considering the local thermal needs and preferences in older people when designing age-friendly indoor thermal environments.

{"title":"Understanding local thermal comfort and physiological responses in older people under uniform thermal environments","authors":"Yin Tang , Hang Yu , Xianzhun Zhong , Kege Zhang , Huice Mao , Jing Geng , Meng Wang","doi":"10.1016/j.physbeh.2025.114832","DOIUrl":"10.1016/j.physbeh.2025.114832","url":null,"abstract":"<div><div>The ageing population has increased the attention on care services for older people, particularly concerning their health and thermal comfort. However, most existing studies focus on the overall thermal comfort of older people, with insufficient research into their local thermal needs for different body parts, impeding precise thermal adjustments and optimal thermal satisfaction. This study investigated the local thermal comfort and skin temperature of older people under various environmental conditions. The results reveal significant variations in local thermal perceptions across body parts in older people under non-neutral thermal conditions. When wearing standard clothing (long-sleeved shirt and trousers) in cool environments, the back was the coldest part, followed by the lower body. In warm environments, the back, head, and chest exhibited higher thermal sensations. Weighting factors quantifying the influence of local thermal sensations on overall thermal sensation were calculated, identifying the head and back as key regions in warm conditions, and the back, arms, and legs in cool conditions. Local skin temperature also varied significantly across the body, with the head and trunk exhibiting higher temperatures and showing less fluctuation in response to environmental changes compared to the limbs. Furthermore, regression models between local thermal sensation and skin temperature were developed. Compared to the results from young people, older subjects showed significantly smaller variations in local thermal sensations across the body, along with significantly differences in local skin temperatures. These findings highlight the importance of considering the local thermal needs and preferences in older people when designing age-friendly indoor thermal environments.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"292 ","pages":"Article 114832"},"PeriodicalIF":2.4,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NEONATAL CO-ADMINISTRATION OF THE PHYTOESTROGENS GENISTEIN AND DAIDZEIN DISRUPTS SEXUAL BEHAVIOR AND FERTILITY.

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-28 DOI: 10.1016/j.physbeh.2025.114812

Marissa Guillén-Castrillo, Reyna Fierro, Pablo Damián-Matsumura, Saúl Gaona-Domínguez, Rosario Tarragó-Castellanos

Phytoestrogens are non-steroidal compounds that, can act as agonists and/or antagonists by binding to estrogen receptors; hence they can modify estrogen-dependent processes of neonatal sexual differentiation. Results of the analysis of the sexual behavior of experimental rats that received 6.8 mg of isoflavones/kg/day, showed significantly more mating activity, but fewer ejaculations (p<0.01), and a lower copulatory efficiency than the control group. Aggressive behavior was prominent in the phytoestrogen-treated males (p<0.05), but defensive behavior was infrequent. Phytoestrogens may interfere with the development of male and female traits by competing with estradiol in contexts of sexual behavior. Compared to the control group, the phytoestrogen-treated males exhibited delayed olfactory perception and uncertain preference. The ventrolateral area of the medial hypothalamus is influenced by neonatal neuro estrogens that can produce changes in differentiation, such as the aggressiveness manifested by the males. A probable explanation is that this is due to the inhibition of aromatase by isoflavones. Regarding fertility, the females impregnated by the control males had more offspring (12.2 ± 2.10), than those of the experimental males (4.02 ± 1.13, p<0.01). Spermatozoa analysis showed a low concentration (p<0.05) due to isoflavone treatment, with increased immaturity (p<0.01) and more dead spermatozoa (p<0.05). We conclude that neonatal administration of genistein and daidzein alters olfactory functions, aggressiveness, sexual behaviors, and fertility through changes in spermatozoa quality. The most notable effect was the decreased of fertility in experimental male demonstrated by the lower number of pregnant females and smaller litters.

{"title":"NEONATAL CO-ADMINISTRATION OF THE PHYTOESTROGENS GENISTEIN AND DAIDZEIN DISRUPTS SEXUAL BEHAVIOR AND FERTILITY.","authors":"Marissa Guillén-Castrillo, Reyna Fierro, Pablo Damián-Matsumura, Saúl Gaona-Domínguez, Rosario Tarragó-Castellanos","doi":"10.1016/j.physbeh.2025.114812","DOIUrl":"https://doi.org/10.1016/j.physbeh.2025.114812","url":null,"abstract":"<p><p>Phytoestrogens are non-steroidal compounds that, can act as agonists and/or antagonists by binding to estrogen receptors; hence they can modify estrogen-dependent processes of neonatal sexual differentiation. Results of the analysis of the sexual behavior of experimental rats that received 6.8 mg of isoflavones/kg/day, showed significantly more mating activity, but fewer ejaculations (p<0.01), and a lower copulatory efficiency than the control group. Aggressive behavior was prominent in the phytoestrogen-treated males (p<0.05), but defensive behavior was infrequent. Phytoestrogens may interfere with the development of male and female traits by competing with estradiol in contexts of sexual behavior. Compared to the control group, the phytoestrogen-treated males exhibited delayed olfactory perception and uncertain preference. The ventrolateral area of the medial hypothalamus is influenced by neonatal neuro estrogens that can produce changes in differentiation, such as the aggressiveness manifested by the males. A probable explanation is that this is due to the inhibition of aromatase by isoflavones. Regarding fertility, the females impregnated by the control males had more offspring (12.2 ± 2.10), than those of the experimental males (4.02 ± 1.13, p<0.01). Spermatozoa analysis showed a low concentration (p<0.05) due to isoflavone treatment, with increased immaturity (p<0.01) and more dead spermatozoa (p<0.05). We conclude that neonatal administration of genistein and daidzein alters olfactory functions, aggressiveness, sexual behaviors, and fertility through changes in spermatozoa quality. The most notable effect was the decreased of fertility in experimental male demonstrated by the lower number of pregnant females and smaller litters.</p>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":" ","pages":"114812"},"PeriodicalIF":2.4,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Explaining cognitive decline related to hypertension: The role of heart rate variability in the stairway to cognitive impairment

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-27 DOI: 10.1016/j.physbeh.2025.114825

Giuseppe Forte, Maria Casagrande

Until now, it has been challenging to examine what are the causes of the cognitive decline associated with hypertension and to understand the predictive variables that indicate the development of cognitive impairment in people with hypertension. This work is aimed to understand the interplay between heart rate variability and blood pressure and whether their combination can predict cognitive performance. This cross-sectional observational study involved patients with fifty-two adults with essential hypertension and a control group of 41 healthy adults without hypertension. Except for the diagnosis of hypertension the same inclusion criteria were adopted to balance the groups. The overall sample was divided based on HRV metrics. A complete neuropsychological battery was administered and resting heart rate variability in individuals with and without hypertension was measured. Hypertensive patients with altered HRV had worse cognitive performance, particularly in the executive domain. Low HRV and hypertension have interdependent and combined association with cognitive impairment. Our results indicate that the association between hypertension and cognitive performance is affected by HRV. For neuroscientists, it's time to look beyond the brain. And clinicians who treat the body can't assume that the brain is above involvement.

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引用次数: 0

Dissociation of circadian rhythms in adolescent rats affects object recognition and spatial recognition memories

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-27 DOI: 10.1016/j.physbeh.2025.114824

Karen Cristina Pugliane , Rochele Castelo-Branco , Kathlyn Kamoly Barbosa Cavalcanti Araújo , Jeane Constantino Pereira , Júlio César de Oliveira Leal , Bruna Del Vechio Koike , John Fontenele-Araujo , Crhistiane Andressa da Silva , Flavio Freitas Barbosa

The T22 protocol is an animal model of forced internal desynchronization, in which rats are exposed to an 11:11 light-dark (LD) cycle. This non-invasive protocol induces the dissociation of circadian rhythms in adult rats, making it possible to study the effects of circadian disruption on physiological and behavioral processes such as learning, memory, and emotional responses. However, the effects of circadian dissociation during other developmental stages, such as adolescence, remain unexplored. Adolescence is a period marked by significant changes in sleep patterns and increased exposure to bright light at night, making it essential to investigate how circadian dissociation may affect this phase of development. This study aimed to evaluate the circadian rhythmicity, cognitive performance and anxiety-like behavior in adolescent Wistar rats under the alignment (aligned T22 group) or misalignment (misaligned T22 group) phases of the T22 cycle. A third group of adolescent rats was maintained in a normal 12:12 LD cycle during the experiment and was used as control group (T24 group). Compared to the control group, adolescent rats under both phases of the T22 cycle exhibited a dissociated circadian rhythm of the locomotor activity and deficits in object recognition memory tasks, without impairments in tasks related to emotional responses. These findings indicate that forced desynchronization impairs recognition memory in adolescent rats, suggesting potential cognitive consequences of internal desynchronization during this critical developmental phase, with relevant implications for public health discussions.

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引用次数: 0

Effects of electroacupuncture per-conditioning at Huantiao on motor function recovery in acute cerebral ischemia mice

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-26 DOI: 10.1016/j.physbeh.2025.114814

Jia-le Fu , Jing-Jun Zhang , Yi Wu , Nian-hong Wang , Qi Qi , Guo-hui Yang , Na Ren , Dan Huang , Yun Li , Li-juan Zhao , Xiao Cui , Xiao Xiao , Hong-yu Xie

Background

Continuous electroacupuncture pre-conditioning (EPRC) and post-conditioning (EPOC) effectively improve motor dysfunction after acute cerebral ischemia, but they require multiple treatments. Recently, electroacupuncture per-conditioning (EPEC) has demonstrated neuroprotective effects, indicating that this single-session intervention has short-term efficacy.

Objective

To evaluate the effect of EPEC at Huantiao (GB30) on motor recovery in acute cerebral ischemia mice.

Methods

Forty-eight male C57 BL/6 mice were divided into three groups: Sham(n = 12), Middle Cerebral Artery Occlusion Reperfusion, MCAO/R (n = 18), and Electroacupuncture, EA (n = 18). The EA group received 60 minutes of electroacupuncture during the ischemic phase. Cerebral blood flow was measured with a laser system, and neurological assessments, brain infarct volume, and neuronal damage were made at 24-, 48-, and 72-hours post-surgery. Motor recovery was tested on day 6, and inflammatory cytokines were measured on day 7.

Results

EPEC at Huantiao (GB30) significantly improves motor function recovery in acute cerebral ischemia mice(p < 0.05), Significantly reducing cerebral infarct volume(p < 0.05) and mitigating neuronal damage and apoptosis(p < 0.05). It also promotes the restoration of cerebral blood flow during ischemia and regulates gradual restoration of cerebral blood flow in early reperfusion(p < 0.05), potentially reducing reperfusion injury. Additionally, it decreases pro-inflammatory factors such as IL-2, IL-8, and IFN-γ(p < 0.05).

Conclusion

EPEC at Huantiao (GB30) significantly improves motor recovery in acute cerebral ischemia mice by reducing infarct size, lessening neuronal damage and apoptosis, increasing cerebral blood flow during ischemia, regulating gradual restoration of cerebral blood flow in early reperfusion, decreasing pro-inflammatory factors, and alleviating reperfusion injury.

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引用次数: 0