Effect of green-lipped mussel (Perna canaliculus) supplementation on faecal microbiota, body composition and iron status markers in overweight and obese postmenopausal women: a randomised, double-blind, placebo-controlled trial.

IF 2.4 Q3 NUTRITION & DIETETICS Journal of Nutritional Science Pub Date : 2023-05-18 eCollection Date: 2023-01-01 DOI:10.1017/jns.2023.41
Maryam Abshirini, Jane Coad, Frances M Wolber, Pamela von Hurst, Matthew R Miller, Hong Sabrina Tian, Marlena C Kruger
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Abstract

The present study aimed to determine the effect of whole meat GSM powder on gut microbiota abundance, body composition and iron status markers in healthy overweight or obese postmenopausal women. This was a 3-months trial involving forty-nine healthy postmenopausal women with body mass index (BMI) between 25 and 35 kg/m2 who were randomly assigned to receive 3 g/d of either GSM powder (n 25) or placebo (n 24). The gut microbe abundance, serum iron status markers and body composition were measured at the baseline and the end of the study. The between-group comparison at the baseline showed a lower abundance of Bacteroides and Clostridium XIVa in the GSM group compared with the placebo (P = 0⋅04). At the baseline, the body fat (BF)% and gynoid fat% were higher in the GSM group compared with the placebo (P < 0⋅05). No significant changes were found in any of the outcome measures, except for ferritin levels that showed a significant reduction over time (time effect P = 0⋅01). Some trend was observed in bacteria including Bacteroides and Bifidobacterium which tended to increase in the GSM group while their abundance decreased or remained at their baseline level in the control group. Supplementation with GSM powder did not result in any significant changes in gut microbe abundance, body composition and iron markers compared with placebo. However, some commensal bacteria such as Bacteroides and Bifidobacteria tended to increase following supplementation with GSM powder. Overall, these findings can expand the knowledge surrounding the effects of whole GSM powder on these outcome measures in healthy postmenopausal women.

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补充绿唇贻贝(Perna canaliculus)对超重和肥胖绝经后妇女粪便微生物群、身体成分和铁状况指标的影响:随机、双盲、安慰剂对照试验。
本研究旨在确定全肉 GSM 粉对健康的超重或肥胖绝经后妇女的肠道微生物群丰度、身体成分和铁状况指标的影响。这项为期 3 个月的试验涉及 49 名身体质量指数(BMI)介于 25 至 35 kg/m2 之间的健康绝经后妇女,她们被随机分配到每天摄入 3 克全麦粉(25 人)或安慰剂(24 人)。在基线和研究结束时测量肠道微生物丰度、血清铁状况指标和身体成分。基线时的组间比较显示,与安慰剂相比,全球通组的乳酸杆菌和梭状芽孢杆菌的丰度较低(P = 0⋅04)。在基线时,与安慰剂相比,全球通组的体脂(BF)%和雌性脂肪%更高(P < 0⋅05)。除了铁蛋白水平随着时间的推移有明显下降外(时间效应 P = 0⋅01),其他结果指标均无明显变化。在细菌(包括乳酸杆菌和双歧杆菌)中观察到一些趋势,在全球通组中,这些细菌的数量呈上升趋势,而在对照组中,它们的数量减少或保持在基线水平。与安慰剂相比,补充 GSM 粉不会导致肠道微生物丰度、身体成分和铁指标发生任何显著变化。不过,一些共生菌(如乳酸杆菌和双歧杆菌)在补充 GSM 粉后有增加的趋势。总之,这些研究结果可以扩展有关全GSM粉对健康绝经后妇女的这些结果指标的影响的知识。
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来源期刊
Journal of Nutritional Science
Journal of Nutritional Science NUTRITION & DIETETICS-
CiteScore
3.00
自引率
0.00%
发文量
91
审稿时长
7 weeks
期刊介绍: Journal of Nutritional Science is an international, peer-reviewed, online only, open access journal that welcomes high-quality research articles in all aspects of nutrition. The underlying aim of all work should be, as far as possible, to develop nutritional concepts. JNS encompasses the full spectrum of nutritional science including public health nutrition, epidemiology, dietary surveys, nutritional requirements, metabolic studies, body composition, energetics, appetite, obesity, ageing, endocrinology, immunology, neuroscience, microbiology, genetics, molecular and cellular biology and nutrigenomics. JNS welcomes Primary Research Papers, Brief Reports, Review Articles, Systematic Reviews, Workshop Reports, Letters to the Editor and Obituaries.
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