A Cryptic Sex-Linked Locus Revealed by the Elimination of a Master Sex-Determining Locus in Medaka Fish.

IF 2.4 2区环境科学与生态学 Q2 ECOLOGY American Naturalist Pub Date : 2023-08-01 DOI:10.1086/724840

Jun Kitano, Satoshi Ansai, Shingo Fujimoto, Ryo Kakioka, Mana Sato, Ixchel F Mandagi, Bayu K A Sumarto, Kazunori Yamahira

{"title":"A Cryptic Sex-Linked Locus Revealed by the Elimination of a Master Sex-Determining Locus in Medaka Fish.","authors":"Jun Kitano, Satoshi Ansai, Shingo Fujimoto, Ryo Kakioka, Mana Sato, Ixchel F Mandagi, Bayu K A Sumarto, Kazunori Yamahira","doi":"10.1086/724840","DOIUrl":null,"url":null,"abstract":"AbstractSex chromosomes rapidly turn over in several taxonomic groups. Sex chromosome turnover is generally thought to start with the appearance of a new sex-determining gene on an autosome while an old sex-determining gene still exists, followed by the fixation of the new one. However, we do not know how prevalent the transient state is, where multiple sex-determining loci coexist within natural populations. Here, we removed a Y chromosome with a master male-determining gene DMY from medaka fish using high temperature-induced sex-reversed males. After four generations, the genomic characteristics of a sex chromosome were found on one chromosome, which was an autosome in the original population. Thus, the elimination of a master sex-determining locus can reveal a cryptic locus with a possible sex-determining effect, which can be the seed for sex chromosome turnover. Our results suggest that populations that seem to have a single-locus XY system may have other chromosomal regions with sex-determining effects. In conclusion, the coexistence of multiple sex-determining genes in a natural population may be more prevalent than previously thought. Experimental elimination of a master sex-determining locus may serve as a promising method for finding a locus that can be a protosex chromosome.","PeriodicalId":50800,"journal":{"name":"American Naturalist","volume":"202 2","pages":"231-240"},"PeriodicalIF":2.4000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Naturalist","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1086/724840","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

AbstractSex chromosomes rapidly turn over in several taxonomic groups. Sex chromosome turnover is generally thought to start with the appearance of a new sex-determining gene on an autosome while an old sex-determining gene still exists, followed by the fixation of the new one. However, we do not know how prevalent the transient state is, where multiple sex-determining loci coexist within natural populations. Here, we removed a Y chromosome with a master male-determining gene DMY from medaka fish using high temperature-induced sex-reversed males. After four generations, the genomic characteristics of a sex chromosome were found on one chromosome, which was an autosome in the original population. Thus, the elimination of a master sex-determining locus can reveal a cryptic locus with a possible sex-determining effect, which can be the seed for sex chromosome turnover. Our results suggest that populations that seem to have a single-locus XY system may have other chromosomal regions with sex-determining effects. In conclusion, the coexistence of multiple sex-determining genes in a natural population may be more prevalent than previously thought. Experimental elimination of a master sex-determining locus may serve as a promising method for finding a locus that can be a protosex chromosome.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

通过消除一个主要的性别决定位点，揭示了一个神秘的性别连锁位点。

摘要性染色体在几个分类类群中迅速翻转。性染色体更替通常被认为始于常染色体上新的性别决定基因的出现，而旧的性别决定基因仍然存在，然后是新基因的固定。然而，我们不知道在自然种群中多个性别决定基因座共存的瞬时状态有多普遍。在这里，我们从高温诱导的性别逆转雄性medaka鱼中去除一条带有主要雄性决定基因DMY的Y染色体。四代后，在一条染色体上发现了性染色体的基因组特征，这条染色体在原群体中是常染色体。因此，消除一个主性别决定位点可以揭示一个可能具有性别决定作用的隐性位点，这可能是性染色体更替的种子。我们的研究结果表明，似乎具有单位点XY系统的人群可能具有其他具有性别决定作用的染色体区域。总之，在一个自然种群中，多种决定性别的基因共存的情况可能比以前认为的更为普遍。实验消除一个主要的性别决定位点可能作为一个有希望的方法来寻找一个位点，可以是一个原性染色体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

American Naturalist 环境科学-进化生物学

CiteScore

5.40

自引率

3.40%

发文量

194

审稿时长

3 months

期刊介绍： Since its inception in 1867, The American Naturalist has maintained its position as one of the world''s premier peer-reviewed publications in ecology, evolution, and behavior research. Its goals are to publish articles that are of broad interest to the readership, pose new and significant problems, introduce novel subjects, develop conceptual unification, and change the way people think. AmNat emphasizes sophisticated methodologies and innovative theoretical syntheses—all in an effort to advance the knowledge of organic evolution and other broad biological principles.