Tamoxifen related chorioretinal structural changes.

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY Cutaneous and Ocular Toxicology Pub Date : 2023-09-01 DOI:10.1080/15569527.2023.2220388
İnci Elif Erbahçeci Timur, Vehbi Açıkgöz, Nagihan Uğurlu, Bülent Yalçın, Mehmet Ali Nahit Şendur, Mutlu Hızal, Halil Kara
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Abstract

Purpose: To evaluate the vascular structure of the choroid and each retinal layer in patients with breast cancer on tamoxifen therapy and compare them with healthy subjects.

Materials and methods: 124 eyes of 62 patients with breast cancer who were on tamoxifen therapy (group 1) and 80 eyes of 40 healthy controls (group 2) were included in this prospective cohort study. The structure of the choroid was evaluated using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) and choroidal binarisation. Spectral-domain OCT (SD-OCT) was performed to analyse the peripapillary nerve fibre layer thickness (pRNFL) and each retinal layer thickness. A subgroup analysis was performed based on chemotherapy history in Group 1. All parameters were compared between Group 1 and the healthy controls and between the subgroups of Group 1.

Results: The subfoveal choroidal thickness and temporal and nasal directions were increased in Group 1 when compared with Group 2 (p < 0.05, each comparison). Choroidal vascularity index was significantly decreased in Group 1 compared with Group 2 (63.15 ± 3.11% and 65.37 ± 4.63%, p < 0.001). There were no significant differences in each retinal layer, pRNFL thickness, and choroid structural parameters between the subgroups of Group 1.

Conclusions: Increased choroidal thickness may be the initial finding of subclinical tamoxifen-induced retinopathy. Patients with breast cancer undergoing tamoxifen therapy may be screened prior to tamoxifen therapy and followed during treatment by SD-OCT.

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他莫昔芬相关的视网膜结构改变。
目的:评价乳腺癌患者接受他莫昔芬治疗后脉络膜及视网膜各层血管结构的变化,并与健康人进行比较。材料和方法:本前瞻性队列研究包括62例接受他莫昔芬治疗的乳腺癌患者124只眼(第一组)和40例健康对照者80只眼(第二组)。使用增强深度成像光谱域光学相干断层扫描(edii - oct)和脉络膜二值化来评估脉络膜的结构。采用光谱域OCT (SD-OCT)分析乳头周围神经纤维层厚度(pRNFL)和视网膜各层厚度。第一组根据化疗史进行亚组分析。比较1组与健康对照组及1组各亚组间各项指标。结果:与2组相比,1组患者中央凹下脉络膜厚度、颞部及鼻腔方向均增加(p p)。结论:脉络膜厚度增加可能是亚临床他莫昔芬所致视网膜病变的初步表现。接受他莫昔芬治疗的乳腺癌患者可以在他莫昔芬治疗前进行筛查,并在治疗期间进行SD-OCT随访。
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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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