Valve-sparing operations after Ross procedure: a single-center experience.

IF 3.3 2区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Annals of cardiothoracic surgery Pub Date : 2023-07-31 DOI:10.21037/acs-2023-avs2-0100
Jama Jahanyar, Bardia Arabkhani, Luca Zanella, Laurent de Kerchove, Peter I Tsai, Gaby Aphram, Stefano Mastrobuoni, Gebrine El Khoury
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Abstract

Background: The Ross procedure has demonstrated excellent long-term results, with restoration of life-expectancy in patients with severe aortic valve dysfunction. However, reintervention after Ross can occur, and herein we describe our center's experience with redo surgery after previous Ross procedures.

Methods: We searched our prospective database for aortic valve-repair and recruited all adult (≥18 years) patients who have undergone valve-sparing root replacements (VSRRs) and/or aortic valve-repair after Ross procedure between July 2001 and July 2022. Univariable logistic regression analysis was performed to identify variables affecting early mortality. Survival, freedom-from-valve-reintervention and freedom-from-aortic regurgitation (AR) grade ≥3 were analyzed with the Kaplan-Meier method.

Results: A total of 63 patients were recruited for this study. Indication for reoperation after Ross was aortic aneurysm without AR in 17 (27%), aortic aneurysm with AR in 27 (43%), and isolated AR in 19 (30%) patients. Median follow-up time was 7.82 years. The majority of patients (76%) had undergone the free root technique during their index Ross operation. Cumulative survival, after redo surgery following Ross, was 98.4% [95% confidence interval (CI): 89.3-99.8%] at 1 year, 96.3% (95% CI: 88.2-98.3%) at 5 years, and 92.4% (95% CI: 87.1-98.0%) at 10 years. Freedom-from-reoperation on the aortic valve at 1 year was 98.4% (95% CI: 97.0-99.8%), at 5 years was 96.7% (95% CI: 87.6-99.0%), and 79.7% (95% CI: 71.1-88.3%) at 10 years.

Conclusions: Long-term survival after redo surgery following the Ross operation is excellent. The data support our aggressive valve-sparing approach after Ross.

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罗斯手术后保留瓣膜手术:单中心经验。
背景:Ross手术已经证明了良好的长期效果,可以恢复严重主动脉瓣功能障碍患者的预期寿命。然而,罗斯手术后的再干预也可能发生,在此我们描述本中心在之前的罗斯手术后再做手术的经验。方法:我们检索了主动脉瓣修复的前瞻性数据库,并招募了2001年7月至2022年7月期间在Ross手术后接受保留瓣膜根置换(VSRRs)和/或主动脉瓣修复的所有成人(≥18岁)患者。采用单变量logistic回归分析确定影响早期死亡率的变量。生存率、无瓣膜再干预和无主动脉反流(AR)≥3级采用Kaplan-Meier法进行分析。结果:本研究共招募了63例患者。Ross术后再手术指征为无AR主动脉瘤17例(27%),合并AR主动脉瘤27例(43%),孤立AR 19例(30%)。中位随访时间为7.82年。大多数患者(76%)在其指数Ross手术中进行了游离根技术。Ross术后重做手术后,1年的累积生存率为98.4%[95%可信区间(CI): 89.3-99.8%], 5年的累积生存率为96.3% (95% CI: 88.2-98.3%), 10年的累积生存率为92.4% (95% CI: 88.1 -98.0%)。1年时主动脉瓣再手术自由率为98.4% (95% CI: 97.0-99.8%), 5年时为96.7% (95% CI: 87.6-99.0%), 10年时为79.7% (95% CI: 71.1-88.3%)。结论:Ross手术后重做术后长期生存率高。罗斯手术后的数据支持我们积极保留瓣膜的方法。
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