Curative Polyendocrine Therapy in a 21-year-Old Patient with Endometrial Carcinoma: Case Report and Review of the Literature.

IF 2 4区 医学 Q3 ONCOLOGY Oncology Research and Treatment Pub Date : 2023-01-01 DOI:10.1159/000531661
Henning Schäffler, Moritz Dimpfl, Fabienne Schochter, Wolfgang Janni, Nikolaus de Gregorio
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Abstract

Introduction: As the numbers of young patients diagnosed with early-stage endometrial carcinoma continue to rise, the question regarding fertility-preserving therapeutic options will increasingly gain significance in the future.

Case presentation: Here, we present the case of a 21-year-old patient diagnosed with symptomatic atypical endometrial hyperplasia. After 4 months of treatment with medroxyprogesterone acetate, a follow-up dilatation and curettage revealed early-stage, well-differentiated endometrioid endometrial carcinoma. Despite national guidelines recommending hysterectomy, the nulliparous patient expressed a desire to preserve her fertility. Subsequently, she underwent polyendocrine therapy with letrozole, everolimus, metformin, and Zoladex. Forty-three months after diagnosis, the patient successfully gave birth to a healthy child, and there have been no indications of recurrence thus far.

Discussion: This case suggests that triple endocrine therapy may be an option for selected patients with early endometrial cancer and a desire for fertility-sparing therapy.

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21岁子宫内膜癌多内分泌治疗1例报告及文献复习。
引言:随着诊断为早期子宫内膜癌的年轻患者数量不断增加,关于保留生育能力的治疗选择的问题将在未来变得越来越重要。病例介绍:在此,我们报告一位21岁的患者被诊断为有症状的不典型子宫内膜增生。经醋酸甲孕酮治疗4个月后,随访扩张刮除显示为早期高分化子宫内膜样子宫内膜癌。尽管国家指南推荐子宫切除术,但未生育的患者表达了保留其生育能力的愿望。随后,她接受了来曲唑、依维莫司、二甲双胍和唑拉迪克斯的多内分泌治疗。确诊43个月后,患者成功生下了一个健康的孩子,到目前为止没有复发的迹象。讨论:本病例提示,三联内分泌治疗可能是选择早期子宫内膜癌患者和生育保留治疗的愿望的一种选择。
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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
84
期刊介绍: With the first issue in 2014, the journal ''Onkologie'' has changed its title to ''Oncology Research and Treatment''. By this change, publisher and editor set the scene for the further development of this interdisciplinary journal. The English title makes it clear that the articles are published in English – a logical step for the journal, which is listed in all relevant international databases. For excellent manuscripts, a ''Fast Track'' was introduced: The review is carried out within 2 weeks; after acceptance the papers are published online within 14 days and immediately released as ''Editor’s Choice'' to provide the authors with maximum visibility of their results. Interesting case reports are published in the section ''Novel Insights from Clinical Practice'' which clearly highlights the scientific advances which the report presents.
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