Health Digital Twins in Life Science and Health Care Innovation.

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY Annual review of pharmacology and toxicology Pub Date : 2024-01-23 Epub Date: 2023-08-10 DOI:10.1146/annurev-pharmtox-022123-022046
Kaushik P Venkatesh, Gabriel Brito, Maged N Kamel Boulos
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引用次数: 0

Abstract

Health digital twins (HDTs) are virtual representations of real individuals that can be used to simulate human physiology, disease, and drug effects. HDTs can be used to improve drug discovery and development by providing a data-driven approach to inform target selection, drug delivery, and design of clinical trials. HDTs also offer new applications into precision therapies and clinical decision making. The deployment of HDTs at scale could bring a precision approach to public health monitoring and intervention. Next steps include challenges such as addressing socioeconomic barriers and ensuring the representativeness of the technology based on the training and validation data sets. Governance and regulation of HDT technology are still in the early stages.

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生命科学和医疗保健创新中的健康数字双胞胎。
健康数字双胞胎(HDTs)是真实个体的虚拟代表,可用于模拟人体生理、疾病和药物作用。HDT 可用于改进药物的发现和开发,提供一种数据驱动的方法,为靶点选择、给药和临床试验设计提供信息。HDT 还为精准治疗和临床决策提供了新的应用。大规模部署 HDT 可以为公共卫生监测和干预提供一种精准方法。接下来的步骤包括应对社会经济障碍和确保基于训练和验证数据集的技术代表性等挑战。人类发展数据技术的治理和监管仍处于早期阶段。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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