An update on studies characterizing adaptive immune responses in SARS-CoV-2 infection and COVID-19 vaccination.

IF 4.8 4区 医学 Q2 IMMUNOLOGY International immunology Pub Date : 2023-08-07 DOI:10.1093/intimm/dxad014
Ricardo da Silva Antunes, Alba Grifoni, April Frazier, Daniela Weiskopf, Alessandro Sette
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Abstract

In this brief opinion piece, we highlight our studies characterizing adaptive SARS-CoV-2 immune responses in infection and vaccination, and the ability of SARS-CoV-2-specific T cells to recognize emerging variants of concern, and the role of pre-existing cross-reactive T cells. In the context of the debate on correlates of protection, the pandemic's progression in the past 3 years underlined the need to consider how different adaptive immune responses might differentially contribute to protection from SARS-CoV-2 infection versus COVID-19 disease. Lastly, we discuss how cross-reactive T cell responses may be useful in generating a broad adaptive immunity, recognizing different variants and viral families. Considering vaccines with broadly conserved antigens could improve preparedness for future infectious disease outbreaks.

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关于 SARS-CoV-2 感染和 COVID-19 疫苗接种中适应性免疫反应特征的最新研究。
在这篇简短的评论文章中,我们重点介绍了我们的研究,这些研究描述了在感染和接种疫苗过程中 SARS-CoV-2 适应性免疫反应的特征、SARS-CoV-2 特异性 T 细胞识别新出现的相关变异体的能力以及原有交叉反应 T 细胞的作用。在关于保护相关性的讨论中,过去 3 年中大流行病的发展突显出有必要考虑不同的适应性免疫反应可能如何对 SARS-CoV-2 感染和 COVID-19 疾病的保护起到不同的作用。最后,我们讨论了交叉反应性 T 细胞反应如何有助于产生广泛的适应性免疫,识别不同的变体和病毒家族。考虑使用具有广泛保守抗原的疫苗可以提高对未来传染病爆发的防范能力。
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来源期刊
International immunology
International immunology 医学-免疫学
CiteScore
9.30
自引率
2.30%
发文量
51
审稿时长
6-12 weeks
期刊介绍: International Immunology is an online only (from Jan 2018) journal that publishes basic research and clinical studies from all areas of immunology and includes research conducted in laboratories throughout the world.
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