Understanding cancer etiology: A review of the evidence-based Ayurvedic framework of cancer etiologies.

Ayu Pub Date : 2022-01-01 Epub Date: 2023-06-24 DOI:10.4103/ayu.ayu_318_21
Amulya Murthy Aku, Ashok Patil
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Abstract

Background of the study: As many as 10 million people have died from cancer globally in 2020, making it the top cause of mortality in the globe. Cancer develops as a result of the multi-stage process by which normal cells convert into tumor cells, progressing from a precancerous lesion to a malignant tumor. By avoiding risk factors and applying existing evidence-based preventative techniques, 30%-50% of malignancies may be averted. In order to avoid cancer, it is essential to know the specific causes of the disease. Nidanas, or etiologies, are well-described in Ayurvedic science. Here, the causes of cancer have been outlined so that the knowledge may be used effectively to avoid the disease.

Aims: Identification of cancer etiologies that have been described in classics. Evidence-based understanding of these etiologies and to comprehend the significance of etiologies in cancer prevention.

Materials and methods: A thorough evaluation of literature, including ancient Ayurvedic classics, modern medical texts, and articles published in reputable journals, was conducted to meet the study's goals and objectives.

Results: According to Ayurveda, there are three distinct phases of tumorigenesis: chronic inflammation, precancerous development, Granthi (a benign glandular swelli ng), and Arbuda (a precancerous tumor) (definite malignancy). A growing body of evidence suggests that the tumor microenvironment, which is predominantly controlled by inflammatory cells, is an essential player in the neoplastic process.

Conclusion: Although inflammation is coming into the picture just now in the contemporary world, Ayurveda has described this as a leading cause 5000 years back. It is evident that diet and lifestyle play a crucial role in the etiology of Shoth (inflammation).

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理解癌症病因:对癌症病因循证阿育吠陀框架的回顾。
研究背景:2020年,全球多达1000万人死于癌症,使其成为全球最主要的死亡原因。癌症是正常细胞转化为肿瘤细胞,从癌前病变发展为恶性肿瘤的多阶段过程的结果。通过避免危险因素并应用现有的循证预防技术,可以避免30%-50%的恶性肿瘤。为了避免癌症,了解疾病的具体原因是至关重要的。Nidanas,或称病因,在阿育吠陀科学中有很好的描述。本文概述了癌症的病因,以便有效利用这些知识来避免这种疾病。目的:鉴定癌症的病因,这些病因在经典著作中已有描述。对这些病因的循证理解,并理解病因在癌症预防中的意义。材料和方法:对文献进行了全面评估,包括古代阿育吠陀经典、现代医学文献和在知名期刊上发表的文章,以达到研究的目标和目的。结果:根据阿育吠陀,肿瘤发生有三个不同的阶段:慢性炎症、癌前发展、Granthi(一种良性腺体肿胀)和Arbuda(一种癌前肿瘤)(明确的恶性肿瘤)。越来越多的证据表明,主要由炎症细胞控制的肿瘤微环境是肿瘤过程中的重要参与者。结论:尽管炎症刚刚在当代世界出现,但阿育吠陀在5000年前就将其描述为主要原因。很明显,饮食和生活方式在Shoth(炎症)的病因中起着至关重要的作用。
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