Possible development and resolution of dilated cardiomyopathy phenotype secondary to atypical hypoadrenocorticism in a dog

IF 1.1 3区 农林科学 Q3 VETERINARY SCIENCES Journal of veterinary emergency and critical care Pub Date : 2023-08-14 DOI:10.1111/vec.13321
Alexandra H. Riggs DVM, Jaylyn Rhinehart DVM, MS, DACVIM, Edward S. Cooper VMD, MS, DACVECC
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Abstract

Objective

To report the possible occurrence of dilated cardiomyopathy phenotype associated with atypical hypoadrenocorticism and subsequent marked improvement with treatment in a mixed breed dog.

Case Summary

A 4.5-year-old, neutered male mixed breed dog was evaluated for a history and clinicopathological changes consistent with atypical hypoadrenocorticism. The dog was being fed a grain-free diet. While hospitalized for supportive care and diagnostics, the patient developed and was diagnosed with biventricular congestive heart failure secondary to dilated cardiomyopathy phenotype and IV fluid administration. The left-sided congestive heart failure resolved with discontinuation of IV fluid therapy and short-term administration of diuretics. After treatment of atypical hypoadrenocorticism with glucocorticoid supplementation, and while continuing to be fed varying grain-free diets, the patient's dilated cardiomyopathy phenotype largely resolved. The patient fully recovered and did not require any long-term cardiac medications.

New or Unique Information Provided

Development of dilated cardiomyopathy phenotype has not been described in dogs as a sequela of untreated hypoadrenocorticism but has been reported in human literature. Given the fact that standard management of hypoadrenocorticism typically involves aggressive fluid resuscitation, awareness of this potential sequela is important for patients that fail to respond or develop signs consistent with volume overload.

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犬继发于非典型肾上腺皮质功能减退的扩张型心肌病表型的可能发展和解决。
目的:报道一只混合品种犬可能出现的扩张型心肌病表型与非典型肾上腺皮质功能减退相关,并随后通过治疗得到显著改善。病例总结:对一只4.5岁的绝育雄性混合品种犬的病史和临床病理变化进行了评估,其与非典型肾上腺皮质功能减退症一致。这只狗正在接受无谷物饮食。在住院接受支持性护理和诊断期间,患者发展并被诊断为双心室充血性心力衰竭,继发于扩张型心肌病表型和静脉输液。左侧充血性心力衰竭通过停止静脉输液治疗和短期服用利尿剂而得到解决。在补充糖皮质激素治疗非典型肾上腺皮质功能减退症后,在继续喂食不同的无谷物饮食的同时,患者的扩张型心肌病表型基本上得到了解决。患者完全康复,不需要任何长期的心脏药物治疗。提供了新的或独特的信息:扩张型心肌病表型的发展尚未在狗身上被描述为未经治疗的肾上腺皮质功能减退的后遗症,但在人类文献中已有报道。鉴于肾上腺皮质功能减退症的标准治疗通常涉及积极的液体复苏,对这种潜在后遗症的认识对于那些没有反应或出现与容量过载一致的体征的患者来说很重要。
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来源期刊
CiteScore
2.50
自引率
15.40%
发文量
121
审稿时长
18-36 weeks
期刊介绍: The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues. The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.
期刊最新文献
Fabio Viganó Jennifer J. Devey Issue Information - Prelim AUTHOR INDEX Abstracts from the International Veterinary Emergency and Critical Care Symposium and the European Veterinary Emergency and Critical Care Annual Congress 2024
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