Benzoates and in situ formed benzene in food supplements and risk assessment.

IF 2.5 3区农林科学 Q2 CHEMISTRY, APPLIED Food additives & contaminants. Part B, Surveillance Pub Date : 2023-12-01 Epub Date: 2023-08-15 DOI:10.1080/19393210.2023.2241145

Sladjana Vojvodić, Branislava Srdjenović Čonić, Ljilja Torović

引用次数: 0

Abstract

Upward trend in the use of food supplements urged the assessment of their safety. Eighty-eight liquid herbal supplements collected in Novi Sad (Serbia) in 2018 (36 samples) and 2021 (52 samples) were analysed for the presence of benzoates and sorbates (HPLC-UV) and benzene (HS-GC/MS). Benzoic acid varied from 599 to 9253 mg/kg and sorbic acid between 185 and 1658 mg/kg. The acceptable daily intake of sorbic acid was not reached, but in case of benzoic acid, it was exceeded by 5.3% of the samples. The presence of benzene was confirmed in 41.2% of benzoate preserved supplements (0.9-51.7 µg/kg). Benzene exposure revealed no health concern: maximum hazard quotients ranged from 0.39% (toddlers) to 0.84% (adolescents); minimum margins of exposure were between 35,680 (adolescents) and 77,419 (toddlers); estimates of lifetime cancer risk did not reach one extra cancer case per 100 000 persons. However, measures to mitigate benzene presence in food should be considered.

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食品添加剂中苯甲酸盐和原位形成苯及其风险评估。

食品补充剂使用量的上升趋势促使人们对其安全性进行评估。对2018年(36个样本)和2021年(52个样本)在塞尔维亚诺维萨德采集的88种液体草药补充剂进行了苯甲酸盐和山梨酸酯(HPLC-UV)和苯(HS-GC/MS)的分析。苯甲酸为599 ~ 9253 mg/kg，山梨酸为185 ~ 1658 mg/kg。山梨酸的日摄取量未达到标准，苯甲酸的日摄取量超标5.3%。41.2%的苯甲酸盐保存补充剂中确认存在苯(0.9-51.7µg/kg)。苯暴露对健康没有影响:最大危害商数从0.39%(幼儿)到0.84%(青少年)不等;最小暴露量介于35,680(青少年)和77,419(幼儿)之间;对终生癌症风险的估计没有达到每10万人中增加一例癌症病例。然而，应该考虑采取措施减少食品中苯的存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food additives & contaminants. Part B, Surveillance 农林科学-毒理学

CiteScore

5.30

自引率

10.30%

发文量

审稿时长

2.7 months

期刊介绍： Food Additives & Contaminants: Part B publishes surveillance data indicating the presence and levels of occurrence of designated food additives, residues and contaminants in foods, food supplements and animal feed. Data using validated methods must meet stipulated quality standards to be acceptable and must be presented in a prescribed format for subsequent data-handling. Food Additives & Contaminants: Part B restricts its scope to include certain classes of food additives, residues and contaminants. This is based on a goal of covering those areas where there is a need to record surveillance data for the purposes of exposure and risk assessment. The scope is initially restricted to: Additives - food colours, artificial sweeteners, and preservatives; Residues – veterinary drug and pesticide residues; Contaminants – metals, mycotoxins, phycotoxins, plant toxins, nitrate/nitrite, PCDDs/PCFDs, PCBs, PAHs, acrylamide, 3-MPCD and contaminants derived from food packaging. Readership: The readership includes scientists involved in all aspects of food safety and quality and particularly those involved in monitoring human exposure to chemicals from the diet. Papers reporting surveillance data in areas other than the above should be submitted to Part A . The scope of Part B will be expanded from time-to-time to ensure inclusion of new areas of concern.

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