缺血性中风中的星形胶质细胞:中枢神经系统的相互影响与治疗潜力

IF 1.3 4区 医学 Q4 CLINICAL NEUROLOGY Neuropathology Pub Date : 2024-02-01 Epub Date: 2023-06-21 DOI:10.1111/neup.12928
Jueling Liu, Yuying Guo, Yunsha Zhang, Xiaoxiao Zhao, Rong Fu, Shengyu Hua, Shixin Xu
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引用次数: 0

摘要

在中枢神经系统(CNS)中,一大群被称为星形胶质细胞的胶质细胞在生理和疾病状态下都发挥着重要作用。星形胶质细胞参与神经血管单元的形成,并与中枢神经系统的其他细胞(如小胶质细胞和神经元)密切互动。中风是一种全球性疾病,死亡率和致残率都很高,其中大部分是缺血性中风。过去几十年来,人们在了解星形胶质细胞方面取得了长足进步。星形胶质细胞对缺血性中风的强烈反应过程被称为激活或反应性。鉴于反应性星形胶质细胞(RA)在缺血性中风的不同空间和时间方面所起的重要作用,人们对星形胶质细胞的潜在治疗作用越来越感兴趣。目前,针对星形胶质细胞的干预措施,如介导星形胶质细胞极化、减轻水肿、调节胶质瘢痕的形成以及对星形胶质细胞进行重编程等,在调节缺血性卒中的进展方面已得到证实。本综述将总结上述对星形胶质细胞的潜在干预措施以及星形胶质细胞与中枢神经系统其他细胞之间的相互影响。
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Astrocytes in ischemic stroke: Crosstalk in central nervous system and therapeutic potential.

In the central nervous system (CNS), a large group of glial cells called astrocytes play important roles in both physiological and disease conditions. Astrocytes participate in the formation of neurovascular units and interact closely with other cells of the CNS, such as microglia and neurons. Stroke is a global disease with high mortality and disability rate, most of which are ischemic stroke. Significant strides in understanding astrocytes have been made over the past few decades. Astrocytes respond strongly to ischemic stroke through a process known as activation or reactivity. Given the important role played by reactive astrocytes (RAs) in different spatial and temporal aspects of ischemic stroke, there is a growing interest in the potential therapeutic role of astrocytes. Currently, interventions targeting astrocytes, such as mediating astrocyte polarization, reducing edema, regulating glial scar formation, and reprogramming astrocytes, have been proven in modulating the progression of ischemic stroke. The aforementioned potential interventions on astrocytes and the crosstalk between astrocytes and other cells of the CNS will be summarized in this review.

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来源期刊
Neuropathology
Neuropathology 医学-病理学
CiteScore
4.10
自引率
4.30%
发文量
105
审稿时长
6-12 weeks
期刊介绍: Neuropathology is an international journal sponsored by the Japanese Society of Neuropathology and publishes peer-reviewed original papers dealing with all aspects of human and experimental neuropathology and related fields of research. The Journal aims to promote the international exchange of results and encourages authors from all countries to submit papers in the following categories: Original Articles, Case Reports, Short Communications, Occasional Reviews, Editorials and Letters to the Editor. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.
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