是什么使功能性淀粉样蛋白起作用?

IF 6.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2022-08-01 DOI:10.1080/10409238.2022.2113030
Ansgar B Siemer
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引用次数: 2

摘要

虽然最初是在疾病的背景下被描述的,但交叉β(淀粉样蛋白)原纤维也被发现是所有生命领域的功能实体。然而,交叉β原纤维基序传达生物学功能的具体特性是什么,使它们特别适合于它们的特定用途,并将它们与生物学中发现的其他原纤维区分开来?这篇综述通过论证交叉β原纤维是高度周期性的、稳定的和自模板的结构,其形成伴随着大量的构象变化,导致其核心和框架序列的多聚合。对这些特性的讨论之后,选择功能性交叉β原纤维的例子,展示了通常如何通过利用许多这些特性来实现功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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What makes functional amyloids work?

Although first described in the context of disease, cross-β (amyloid) fibrils have also been found as functional entities in all kingdoms of life. However, what are the specific properties of the cross-β fibril motif that convey biological function, make them especially suited for their particular purpose, and distinguish them from other fibrils found in biology? This review approaches these questions by arguing that cross-β fibrils are highly periodic, stable, and self-templating structures whose formation is accompanied by substantial conformational change that leads to a multimerization of their core and framing sequences. A discussion of each of these properties is followed by selected examples of functional cross-β fibrils that show how function is usually achieved by leveraging many of these properties.

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来源期刊
CiteScore
14.90
自引率
0.00%
发文量
6
期刊介绍: As the discipline of biochemistry and molecular biology have greatly advanced in the last quarter century, significant contributions have been made towards the advancement of general medicine, genetics, immunology, developmental biology, and biophysics. Investigators in a wide range of disciplines increasingly require an appreciation of the significance of current biochemical and molecular biology advances while, members of the biochemical and molecular biology community itself seek concise information on advances in areas remote from their own specialties. Critical Reviews in Biochemistry and Molecular Biology believes that well-written review articles prove an effective device for the integration and meaningful comprehension of vast, often contradictory, literature. Review articles also provide an opportunity for creative scholarship by synthesizing known facts, fruitful hypotheses, and new concepts. Accordingly, Critical Reviews in Biochemistry and Molecular Biology publishes high-quality reviews that organize, evaluate, and present the current status of high-impact, current issues in the area of biochemistry and molecular biology. Topics are selected on the advice of an advisory board of outstanding scientists, who also suggest authors of special competence. The topics chosen are sufficiently broad to interest a wide audience of readers, yet focused enough to be within the competence of a single author. Authors are chosen based on their activity in the field and their proven ability to produce a well-written publication.
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