蛋白质组学研究癌症免疫和改善治疗。

IF 7.9 2区 医学 Q1 IMMUNOLOGY Seminars in Immunopathology Pub Date : 2023-03-01 DOI:10.1007/s00281-022-00980-2
Giulia Franciosa, Anders H Kverneland, Agnete W P Jensen, Marco Donia, Jesper V Olsen
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引用次数: 2

摘要

肿瘤的生存和进展取决于肿瘤细胞逃避免疫识别的能力。对癌症免疫和肿瘤免疫逃逸机制的理解的进步促进了免疫治疗方法的发展。在其他无法治愈的转移性癌症患者中,免疫治疗产生了前所未有的反应率,并有可能持久完全缓解。然而,原发性和获得性耐药机制限制了免疫治疗的疗效。进一步的治疗进展需要更深入地了解免疫细胞和肿瘤之间的相互作用。在过去的十年中,大多数高通量研究集中在DNA和RNA水平上的组学表征。然而,蛋白质是基因组信息的分子效应器;因此,对蛋白质的研究提供了对细胞功能更深入的了解。基于质谱(MS)的蛋白质组学在全系统范围内的最新进展,可以通过分析未充分研究的翻译后修饰、亚细胞蛋白定位、细胞信号传导和蛋白-蛋白相互作用,实现转化和临床发现。在这篇综述中,我们讨论了基于ms的蛋白质组学对肿瘤免疫和癌症免疫治疗的临床前和临床研究结果的潜在贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Proteomics to study cancer immunity and improve treatment.

Cancer survival and progression depend on the ability of tumor cells to avoid immune recognition. Advances in the understanding of cancer immunity and tumor immune escape mechanisms enabled the development of immunotherapeutic approaches. In patients with otherwise incurable metastatic cancers, immunotherapy resulted in unprecedented response rates with the potential for durable complete responses. However, primary and acquired resistance mechanisms limit the efficacy of immunotherapy. Further therapeutic advances require a deeper understanding of the interplay between immune cells and tumors. Most high-throughput studies within the past decade focused on an omics characterization at DNA and RNA level. However, proteins are the molecular effectors of genomic information; therefore, the study of proteins provides deeper understanding of cellular functions. Recent advances in mass spectrometry (MS)-based proteomics at a system-wide scale may allow translational and clinical discoveries by enabling the analysis of understudied post-translational modifications, subcellular protein localization, cell signaling, and protein-protein interactions. In this review, we discuss the potential contribution of MS-based proteomics to preclinical and clinical research findings in the context of tumor immunity and cancer immunotherapies.

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来源期刊
Seminars in Immunopathology
Seminars in Immunopathology 医学-病理学
CiteScore
19.80
自引率
2.20%
发文量
69
审稿时长
12 months
期刊介绍: The aim of Seminars in Immunopathology is to bring clinicians and pathologists up-to-date on developments in the field of immunopathology.For this purpose topical issues will be organized usually with the help of a guest editor.Recent developments are summarized in review articles by authors who have personally contributed to the specific topic.
期刊最新文献
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