外周代谢物的改变是阿尔茨海默病的关键因素。

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Current Alzheimer research Pub Date : 2023-01-01 DOI:10.2174/1567205020666230825091147
Can Sheng, Xu Chu, Yan He, Qingqing Ding, Shulei Jia, Qiguang Shi, Ran Sun, Li Song, Wenying Du, Yuan Liang, Nian Chen, Yan Yang, Xiaoni Wang
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引用次数: 0

摘要

越来越多的证据支持阿尔茨海默病(AD)可视为一种伴有中枢和外周代谢紊乱的代谢性疾病。如今,需要探索新的和潜在的替代标志。基于血液和肠道的外周代谢物可能为疾病机制提供新的生化见解。这些代谢物可以影响大脑能量稳态,维持肠道粘膜完整性,调节宿主免疫系统,可能在AD的认知功能和行为调节中发挥关键作用。近年来,代谢组学已被用于识别AD相关的关键代谢变化,并定义AD疾病发展轨迹中的代谢变化。本综述旨在总结在AD中发生改变的关键血液和微生物源代谢物,并确定AD的潜在代谢生物标志物,为未来的精确治疗调节提供靶点。
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Alterations in Peripheral Metabolites as Key Actors in Alzheimer's Disease.

Growing evidence supports that Alzheimer's disease (AD) could be regarded as a metabolic disease, accompanying central and peripheral metabolic disturbance. Nowadays, exploring novel and potentially alternative hallmarks for AD is needed. Peripheral metabolites based on blood and gut may provide new biochemical insights about disease mechanisms. These metabolites can influence brain energy homeostasis, maintain gut mucosal integrity, and regulate the host immune system, which may further play a key role in modulating the cognitive function and behavior of AD. Recently, metabolomics has been used to identify key AD-related metabolic changes and define metabolic changes during AD disease trajectory. This review aims to summarize the key blood- and microbial-derived metabolites that are altered in AD and identify the potential metabolic biomarkers of AD, which will provide future targets for precision therapeutic modulation.

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来源期刊
Current Alzheimer research
Current Alzheimer research 医学-神经科学
CiteScore
4.00
自引率
4.80%
发文量
64
审稿时长
4-8 weeks
期刊介绍: Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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