核因子-κB在乳腺癌中的临床意义:免疫组化研究。

IF 2.9 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Medical Principles and Practice Pub Date : 2023-01-01 DOI:10.1159/000527828
Mashael Saqer Al-Mutairi, Hany Onsy Habashy
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引用次数: 0

摘要

目的:核因子κB (NF-κB)是一个转录因子超家族,在肿瘤的发生和发展中起关键作用。本研究旨在探讨NF-κB/p65在乳腺癌中的表达及其与肿瘤分级、肿瘤大小、激素受体和HER-2等预后指标的关系。方法:采用免疫组化方法,对99个未经选择的福尔马林固定石蜡包埋的浸润性导管和小叶组织切片进行检测,检测NF-κB/p65、雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体-2 (HER-2)和Ki-67的表达。我们评估了NF-κB/p65与临床病理参数的相关性。结果:NF-κB/p65仅存在于细胞质中,且与大肿瘤(≥2 cm)和高级别肿瘤呈正相关(p < 0.001和p = 0.018)。其他乳腺癌标志物如组织学类型(p = 0.766)、HER-2 (p = 0.416)、PR (p = 0.356)、ER (p = 0.606)与NF-κB/p65的表达无显著相关性。与Ki-67标志物无显著相关性(p = 0.117)。结论:目前的研究表明NF-κB/p65的过表达与肿瘤大小和分级之间存在联系。这表明NF-κB/p65的表达与乳腺癌的侵袭性生物活性有关;阐明导致NF-κB/p65细胞质积累的机制可能会导致新的治疗方法的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Nuclear Factor-κB Clinical Significance in Breast Cancer: An Immunohistochemical Study.

Objectives: Nuclear factor κB (NF-κB) is a superfamily of transcription factors that plays a key role in cancer genesis and progression. The present study aimed to examine the expression of NF-κB/p65 in breast cancer and its relationship with prognostic markers such as tumour grade, tumour size, hormone receptors, and HER-2.

Methods: Ninety-nine unselected formalin-fixed paraffin-embedded invasive ductal and lobular tissue sections were evaluated by immunohistochemistry methods to measure the expression of NF-κB/p65, oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), and Ki-67. We assessed the correlation between NF-κB/p65 and clinicopathological parameters.

Results: NF-κB/p65 was found only in the cytoplasm and positively correlated with large tumours (≥2 cm) and high-grade tumours (p < 0.001 and p = 0.018, respectively). Other breast cancer markers, such as histological type (p = 0.766), HER-2 (p = 0.416), PR (p = 0.356), and ER (p = 0.606), had no significant link with the expression of NF-κB/p65. Furthermore, no significant relation with the Ki-67 marker was detected (p = 0.117).

Conclusions: The current study is indicative of a link between overexpression of NF-κB/p65 and both large tumour size and higher grade. This suggests that the expression of NF-κB/p65 is associated with aggressive biological activity in breast cancer; elucidating the mechanisms that lead to NF-κB/p65 cytoplasmic accumulation could lead to the development of novel therapeutic methods.

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来源期刊
Medical Principles and Practice
Medical Principles and Practice 医学-医学:内科
CiteScore
6.10
自引率
0.00%
发文量
72
审稿时长
6-12 weeks
期刊介绍: ''Medical Principles and Practice'', as the journal of the Health Sciences Centre, Kuwait University, aims to be a publication of international repute that will be a medium for dissemination and exchange of scientific knowledge in the health sciences.
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