27号Whitacre针硬膜外穿刺术在分娩硬膜外镇痛中的疗效:随机单盲对照研究。

Iva Pažur, Ognjen Ožegić, Lada Lijović, Katarina Kličan Jaić, Maja Pešić
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摘要

目的:硬膜穿刺硬膜外穿刺技术是对标准硬膜外穿刺技术的改进。其目的是克服标准硬膜外麻醉的缺点。我们通过使用10ml 0.125%布比卡因硬膜外注射,评估27号脊髓针硬膜外穿刺术是否能提供更高质量的分娩硬膜外镇痛。此外,我们还观察了硬膜外穿刺对硬膜外镇痛的发生、分娩过程和产妇不良反应的影响。方法:设计前瞻性、随机、单盲研究。选择健康无产产妇76例,随机分为硬膜穿刺组和标准硬膜外穿刺组。确认硬膜外间隙后,采用脊柱Whitacre针穿刺硬膜。在这一点上,鞘内给药被省略。两组均给予局麻药混合丸,经硬膜外导管持续输注稀释后的局麻药。采用数值疼痛评定量表对疼痛进行评定。记录两组患者的充值次数和分娩方式。结果:10分钟后,两组报告的数值疼痛评定量表≤3分差异有统计学意义(P=0.028),硬膜穿刺组97.4%的患者在10分钟后达到充分镇痛。两组间在额外服药次数、分娩时间、Bromage评分或产妇结局方面无统计学差异。结论:硬膜穿刺硬膜外镇痛技术能快速起效。然而,对额外奖金的需求仍未改变。它可以安全地用于产科,对分娩过程没有有害影响。
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The Efficacy of Dural Puncture Epidural Performed by 27-gauge Whitacre Needle in Labour Epidural Analgesia: Randomized Single-Blinded Controlled Study.

Objective: Dural puncture epidural technique is refinement of standard epidural technique. Its goal is to overcome drawbacks of standard epidural. We assessed whether dural puncture epidural technique performed by 27-gauge spinal needle would provide higher quality of labour epidural analgesia by using 10 mL epidural bolus of 0.125% bupivacaine. Additionally, the impact of dural puncture epidural on epidural analgesia onset, course of labour and occurrence of maternal side effects was examined.

Methods: We designed prospective, randomized, single-blind study. A total of 76 healthy nulliparous parturients were randomly allocated to dural puncture or standard epidural group. After identification of epidural space, spinal Whitacre needle was used for dural puncture. Intrathecal drug administration was omitted at that point. Both groups received a bolus of local anaesthetic mixture, followed by a continuous infusion of diluted local anaesthetic via epidural catheter. Pain was assessed by numeric pain rating scale. The number of top-ups and mode of delivery were recorded in both groups.

Results: After 10 minutes, there was a statistically significant difference in numeric pain rating scale ≤3 reported (P=0.028), with 97.4% subjects in dural puncture epidural group achieving adequate analgesia after 10 minutes. There was no statistically significant difference in the number of additional boluses, time to delivery, Bromage scale achieved or maternal outcomes between groups.

Conclusion: Dural puncture epidural technique appears to be effective in providing faster onset of epidural analgesia. However, the need for additional boluses remains unchanged. It can be safely used in obstetrics, without deleterious effect on the course of labour.

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