农场动物新出现病毒性疾病的前瞻性疫苗。

Ahmad Mohammad Allam, Mohamed Karam Elbayoumy, Alaa Abdelmoneam Ghazy
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摘要

世界目睹了许多可能威胁动物健康的动物病毒的出现,这些病毒被添加到不断增长的动物病原体名单中。这种情况引起了专家和动物卫生组织的注意,即有必要开展疫苗开发工作。本文旨在探讨农场动物新发病毒性疾病疫苗的前景。实现这一目标的方法是,将重点放在疫苗领域已引入的现代技术和下一代疫苗上,这些疫苗要么正在等待批准的临床开发中,要么已经发现并已应用于动物,结果可接受,如病毒载体疫苗、病毒样颗粒和基于信使rna的平台。此外,它还揭示了区分感染动物和接种动物技术在新发病毒性疾病根除计划中的重要性。探讨了纳米材料的新科学,阐明了其在疫苗学中的作用。最后,讨论了生物信息学或疫苗组学在疫苗设计和开发中的作用及其辅助作用。对已发表的手稿进行审查后得出的结论是,使用传统疫苗被认为是消除新出现疾病的过时方法。然而,这些类型的疫苗被认为是适当的计划,特别是在资源和能力不足的国家。未来疫苗学的目标应该是研制基于基因技术的试验疫苗,并对现有病毒进行持续分析。不管病毒的进化速度如何,新兴病毒的智能基因组学将是选择合适疫苗的门户。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Perspective vaccines for emerging viral diseases in farm animals.

The world has watched the emergence of numerous animal viruses that may threaten animal health which were added to the perpetual growing list of animal pathogens. This emergence drew the attention of the experts and animal health groups to the fact that it has become necessary to work on vaccine development. The current review aims to explore the perspective vaccines for emerging viral diseases in farm animals. This aim was fulfilled by focusing on modern technologies as well as next generation vaccines that have been introduced in the field of vaccines, either in clinical developments pending approval, or have already come to light and have been applied to animals with acceptable results such as viral-vectored vaccines, virus-like particles, and messenger RNA-based platforms. Besides, it shed the light on the importance of differentiation of infected from vaccinated animals technology in eradication programs of emerging viral diseases. The new science of nanomaterials was explored to elucidate its role in vaccinology. Finally, the role of Bioinformatics or Vaccinomics and its assist in vaccine designing and developments were discussed. The reviewing of the published manuscripts concluded that the use of conventional vaccines is considered an out-of-date approach in eliminating emerging diseases. However, these types of vaccines are considered the suitable plan especially in countries with few resources and capabilities. Piloted vaccines that rely on genetic-based technologies with continuous analyses of current viruses should be the aim of future vaccinology. Smart genomics of emerging viruses will be the gateway to choosing appropriate vaccines, regardless of the evolutionary rates of viruses.

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来源期刊
CiteScore
3.70
自引率
3.70%
发文量
29
审稿时长
8 weeks
期刊介绍: Clin Exp Vaccine Res, the official English journal of the Korean Vaccine Society, is an international, peer reviewed, and open-access journal. It covers all areas related to vaccines and vaccination. Clin Exp Vaccine Res publishes editorials, review articles, special articles, original articles, case reports, brief communications, and correspondences covering a wide range of clinical and experimental subjects including vaccines and vaccination for human and animals against infectious diseases caused by viruses, bacteria, parasites and tumor. The scope of the journal is to disseminate information that may contribute to elaborate vaccine development and vaccination strategies targeting infectious diseases and tumors in human and animals. Relevant topics range from experimental approaches to (pre)clinical trials for the vaccine research based on, but not limited to, basic laboratory, translational, and (pre)clinical investigations, epidemiology of infectious diseases and progression of all aspects in the health related issues. It is published printed and open accessed online issues (https://ecevr.org) two times per year in 31 January and 31 July. Clin Exp Vaccine Res is linked to many international databases and is made freely available to institutions and individuals worldwide
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