MSCs治疗COVID-19的新途径

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-09-01 DOI:10.1007/s10561-022-10060-2
Reza Samanipour, Sara Tabatabaee, Mahsa Delyanee, Amirhossein Tavakoli
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引用次数: 2

摘要

针对COVID-19病毒这一不可否认的对人类生命的严重挑战,已经开展了几项正在进行的研究,以制定优化的治疗策略。基于细胞的治疗,特别是间充质干细胞(MSCs)治疗在降低严重急性呼吸综合征冠状病毒2 (SARS-COV-2)的死亡率方面取得了理想的结果,主要是由于其免疫调节作用,可以防止免疫系统的过度激活。此外,这些细胞具有多能性,能够修复受损的肺组织,从而降低急性呼吸窘迫综合征(ARDS)的可能性。虽然这种基于细胞的方法对发展中国家来说不太具有成本效益,但就其治疗SARS-COV-2的有希望的结果而言,应该进行更多的经济评估和临床试验,以改进这种治疗方法。本文将对MSCs治疗COVID-19的功能机制及基于该方法的临床试验进行综述。并对其经济效益进行了讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The promising approach of MSCs therapy for COVID-19 treatment.

Several ongoing investigations have been founded on the development of an optimized therapeutic strategy for the COVID-19 virus as an undeniable acute challenge for human life. Cell-based therapy and particularly, mesenchymal stem cells (MSCs) therapy has obtained desired outcomes in decreasing the mortality rate of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), mainly owing to its immunoregulatory impact that prevents the overactivation of the immune system. Also, these cells with their multipotent nature, are capable of repairing the damaged tissue of the lung which leads to reducing the probability of acute respiratory distress syndrome (ARDS). Although this cell-based method is not quite cost-effective for developing countries, regarding its promising results in order to treat SARS-COV-2, more economical evaluation as well as clinical trials should be performed for improving this therapeutic approach. Here in this article, the functional mechanism of MSCs therapy for the treatment of COVID-19 and the clinical trials based on this method will be reviewed. Moreover, its economic efficiency will be discussed.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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