鞘氨醇1-磷酸在感染和免疫中的信号传导

IF 14 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Progress in lipid research Pub Date : 2023-08-24 DOI:10.1016/j.plipres.2023.101251
Sabira Mohammed , Anu Bindu , Arun Viswanathan , Kuzhuvelil B. Harikumar
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引用次数: 1

摘要

鞘脂是所有真核生物膜的基本成分。生物活性鞘脂分子sphingosin 1-Phosphate (S1P)调节多种重要的生物功能。本文旨在全面综述S1P信号通路在不同病理生理条件下(包括细菌和病毒感染、自身免疫性疾病、炎症和癌症)在各种免疫细胞功能中的作用。我们涵盖了NOD/TLR通路中S1P通路、细菌和病毒感染、自身免疫性疾病和肿瘤免疫学的各个方面。这意味着靶向S1P信号可以作为阻断这些病理的策略。我们目前对靶向S1P信号的各种成分用于治疗目的的理解,以及在宿主免疫系统起关键作用的疾病条件下S1P通路抑制剂或调节剂的现状是本综述的主要重点。
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Sphingosine 1-phosphate signaling during infection and immunity

Sphingolipids are essential components of all eukaryotic membranes. The bioactive sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important biological functions. This review aims to provide a comprehensive overview of the role of S1P signaling pathway in various immune cell functions under different pathophysiological conditions including bacterial and viral infections, autoimmune disorders, inflammation, and cancer. We covered the aspects of S1P pathways in NOD/TLR pathways, bacterial and viral infections, autoimmune disorders, and tumor immunology. This implies that targeting S1P signaling can be used as a strategy to block these pathologies. Our current understanding of targeting various components of S1P signaling for therapeutic purposes and the present status of S1P pathway inhibitors or modulators in disease conditions where the host immune system plays a pivotal role is the primary focus of this review.

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来源期刊
Progress in lipid research
Progress in lipid research 生物-生化与分子生物学
CiteScore
24.50
自引率
2.20%
发文量
37
审稿时长
14.6 weeks
期刊介绍: The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.
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