西酞普兰和文拉法辛治疗癌症妇女热闪光的评价与比较。

IF 1.7 Q3 PHARMACOLOGY & PHARMACY Drug Research Pub Date : 2023-10-01 Epub Date: 2023-08-30 DOI:10.1055/a-2061-7020
Sasan Yaghoobi Taleghani, Farnaz Etesam, Mohsen Esfandbod
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引用次数: 0

摘要

背景:癌症是全世界女性最常见的癌症。过早的更年期和潮热是癌症治疗的主要并发症。在接受化疗的癌症女性中,约有40%至50%出现更年期过早症状,包括潮热。一些内分泌疗法,如三苯氧胺和芳香化酶抑制剂,与诱发或加重潮热有关。潮热通常会使人衰弱,并严重损害日常功能。因此,到目前为止,已经研究了许多治疗方案来治疗这种不良反应。然而,在管理癌症患者的潮热方面仍然存在一些临床挑战。目的:评价和比较文拉法辛和西酞普兰治疗癌症患者服用他莫昔芬后潮热的疗效。设计:我们对41名35至65岁的女性患者进行了一项双盲、安慰剂对照试验。研究持续了四周,随访了两个月。文拉法辛和西酞普兰治疗开始时的剂量为37.5 mg或10 mg。文拉法辛和西酞普兰的剂量在第二周分别增加到75和20 mg。该研究于2017年进行。关键结果:结果表明,西酞普兰、文拉法辛和安慰剂组的总疗效存在显著差异。安慰剂组、文拉法辛组和西酞普兰组的总有效率分别为14.3%、53.8%和64.3%(p=0.02)。第二周,西酞普兰、文拉法新和安慰剂组的有效率分别是57.1%、53.8和14.3%(p=0.04)。总体而言,西酞普和文拉法辛耐受性良好。两组患者的相关不良反应均为轻度至中度。结论:尽管西酞普兰会产生更多的不良反应,包括便秘,但与文拉法辛或安慰剂相比,西酞普兰在降低潮热频率方面更有效。
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Evaluation and Comparison of Citalopram and Venlafaxine for Management of Hot Flashes in Women with Breast Cancer.

Background: Breast cancer is the most common cancer in women worldwide. Premature menopause and hot flashes are the main complications of breast cancer treatments. About 40 to 50 percent of breast cancer women who undergo chemotherapy are experiencing premature menopause symptoms, including hot flashes. Some endocrine therapies such as tamoxifen and aromatase inhibitors are associated with induction or aggravating hot flashes. Hot flashes are often debilitating and significantly impair daily functions. Therefore many therapeutic options have been studied so far for the management of this adverse effect. However, there are still some clinical challenges in managing hot flashes in patients with breast cancer.

Objective: We aimed to evaluate and compare the efficacy of venlafaxine and citalopram on hot flashes in breast cancer women receiving tamoxifen.

Design: We conducted a double-blind, placebo-controlled trial in forty-one, 35 to 65 years old female patients. The study lasted for four weeks, and the follow-up was for two months. Venlafaxine and citalopram treatments started with doses of 37.5 mg or 10 mg, respectively. Venlafaxine and citalopram dosages were increased in the second week to 75 and 20 mg, respectively. The study was conducted during the year 2017.

Key results: The results indicated that the total efficacy was significantly different in groups receiving citalopram, venlafaxine, and placebo. Total efficacy in the placebo group, venlafaxine, and citalopram was 14.3, 53.8, and 64.3%, respectively (p=0.02). During the second week, the efficacy in groups receiving citalopram, venlafaxine, and placebo was 57.1, 53.8, and 14.3%, respectively (p=0.04). Generally, both citalopram and venlafaxine were well tolerated. The associated adverse effects were mild to moderate in both groups.

Conclusions: Although citalopram was associated with more adverse effects, including constipation, it was more effective in reducing the frequency of hot flashes when compared to venlafaxine or placebo.

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来源期刊
Drug Research
Drug Research PHARMACOLOGY & PHARMACY-
CiteScore
3.50
自引率
0.00%
发文量
67
期刊介绍: Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine and the application of biological discoveries in the development of drugs for use in the clinical environment. Articles and experimental data from across the field of drug research address not only the issue of drug discovery, but also the mathematical and statistical methods for evaluating results from industrial investigations and clinical trials. Publishing twelve times a year, Drug Research includes original research articles as well as reviews, commentaries and short communications in the following areas: analytics applied to clinical trials chemistry and biochemistry clinical and experimental pharmacology drug interactions efficacy testing pharmacodynamics pharmacokinetics teratology toxicology.
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