从妊娠期时间中断到非传染性疾病:成人疾病编程的病理生理机制和褪黑素的潜在治疗作用

IF 8.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Journal of Pineal Research Pub Date : 2023-08-31 DOI:10.1111/jpi.12908
Natalia Méndez, Fernando Corvalan, Diego Halabi, Pamela Ehrenfeld, Rodrigo Maldonado, Karina Vergara, Maria Seron-Ferre, Claudia Torres-Farfan
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引用次数: 0

摘要

在妊娠期间,发育中的胎儿依靠精确的母体昼夜节律信号来实现最佳生长和为宫外生活做准备。这些信号调节氧气、营养物质、激素和其他生物物理因素的每日输送,同时使胎儿节律与外部光周期同步。然而,光污染和轮班工作等现代生活方式因素会导致妊娠时间中断,导致母体和胎儿昼夜节律不同步。这种干扰与胎儿心血管、神经发育、代谢和内分泌功能的不良影响有关,增加了成年后对非传染性疾病的易感性。这与健康与疾病的发展起源理论一致,该理论表明,早期接触会对日后的健康结果产生重大影响。妊娠期时间中断的后果也会延伸到成年期。饮食和压力等环境因素会加剧这些干扰的不利影响,强调在整个生命周期中保持健康的昼夜节律对预防非传染性疾病和减轻妊娠时间干扰对衰老的影响的重要性。目前的研究工作旨在确定预防或减轻妊娠时间中断影响的潜在干预措施。妊娠期补充褪黑激素是一种很有前途的干预措施,尽管需要进一步的研究来充分了解所涉及的确切机制,并制定有效的策略来促进受妊娠时间中断影响的个体的健康和预防非传染性疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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From gestational chronodisruption to noncommunicable diseases: Pathophysiological mechanisms of programming of adult diseases, and the potential therapeutic role of melatonin

During gestation, the developing fetus relies on precise maternal circadian signals for optimal growth and preparation for extrauterine life. These signals regulate the daily delivery of oxygen, nutrients, hormones, and other biophysical factors while synchronizing fetal rhythms with the external photoperiod. However, modern lifestyle factors such as light pollution and shift work can induce gestational chronodisruption, leading to the desynchronization of maternal and fetal circadian rhythms. Such disruptions have been associated with adverse effects on cardiovascular, neurodevelopmental, metabolic, and endocrine functions in the fetus, increasing the susceptibility to noncommunicable diseases (NCDs) in adult life. This aligns with the Developmental Origins of Health and Disease theory, suggesting that early-life exposures can significantly influence health outcomes later in life. The consequences of gestational chronodisruption also extend into adulthood. Environmental factors like diet and stress can exacerbate the adverse effects of these disruptions, underscoring the importance of maintaining a healthy circadian rhythm across the lifespan to prevent NCDs and mitigate the impact of gestational chronodisruption on aging. Research efforts are currently aimed at identifying potential interventions to prevent or mitigate the effects of gestational chronodisruption. Melatonin supplementation during pregnancy emerges as a promising intervention, although further investigation is required to fully understand the precise mechanisms involved and to develop effective strategies for promoting health and preventing NCDs in individuals affected by gestational chronodisruption.

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来源期刊
Journal of Pineal Research
Journal of Pineal Research 医学-内分泌学与代谢
CiteScore
17.70
自引率
4.90%
发文量
66
审稿时长
1 months
期刊介绍: The Journal of Pineal Research welcomes original scientific research on the pineal gland and melatonin in vertebrates, as well as the biological functions of melatonin in non-vertebrates, plants, and microorganisms. Criteria for publication include scientific importance, novelty, timeliness, and clarity of presentation. The journal considers experimental data that challenge current thinking and welcomes case reports contributing to understanding the pineal gland and melatonin research. Its aim is to serve researchers in all disciplines related to the pineal gland and melatonin.
期刊最新文献
Cover image RETRACTION: Effects of Melatonin on Fatty Liver Disease: The Role of NR4A1/DNA-Pkcs/P53 Pathway, Mitochondrial Fission, and Mitophagy From Seasonality to Species Conservation: Chronobiological Research on European Hamsters in Strasbourg, France Melatonin Inhibits ET-1 Production to Break Crosstalk Between Prostate Cancer and Bone Cells: Implication for Osteoblastic Bone Metastasis Treatment Issue Information
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