重金属暴露与美国成年人冠心病患病率的相关性:2003年至2018年美国NHANES的研究结果

IF 3.2 3区 环境科学与生态学 Q3 ENGINEERING, ENVIRONMENTAL Environmental Geochemistry and Health Pub Date : 2023-08-01 DOI:10.1007/s10653-023-01670-0
Xi Li, Dongdong Zhang, Yang Zhao, Lei Kuang, Hao Huang, Weiling Chen, Xueru Fu, Yuying Wu, Tianze Li, Jinli Zhang, Lijun Yuan, Huifang Hu, Yu Liu, Fulan Hu, Ming Zhang, Xizhuo Sun, Dongsheng Hu
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引用次数: 0

摘要

我们试图根据美国国家健康与营养检查调查(NHANES, 2003-2018)的数据探索重金属暴露与冠心病(CHD)之间的关系。在分析中,所有参与者的年龄都大于20岁,并且参加了有效冠心病状态的重金属分测试。采用Mann-Kendall检验评估16年来重金属暴露的趋势和冠心病患病率的趋势。采用Spearman等级相关系数和logistic回归(LR)模型估计重金属与冠心病患病率之间的关系。42,749名参与者纳入了我们的分析,其中1802人被诊断为冠心病。16年来,尿中总砷、二甲基胂酸、一甲基胂酸、钡、镉、铅、锑和血液中镉、铅、总汞的暴露水平均呈显著下降趋势(均为Pfor趋势)
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Correlation of heavy metals' exposure with the prevalence of coronary heart disease among US adults: findings of the US NHANES from 2003 to 2018.

We sought to explore the association between heavy metal exposure and coronary heart disease (CHD) based on data from the US National Health and Nutrition Examination Survey (NHANES, 2003-2018). In the analyses, participants were all aged > 20 and had participated in heavy metal sub-tests with valid CHD status. The Mann-Kendall test was employed to assess the trends in heavy metals' exposure and the trends in CHD prevalence over 16 years. Spearman's rank correlation coefficient and a logistics regression (LR) model were used to estimate the association between heavy metals and CHD prevalence. 42,749 participants were included in our analyses, 1802 of whom had a CHD diagnosis. Total arsenic, dimethylarsonic acid, monomethylarsonic acid, barium, cadmium, lead, and antimony in urine, and cadmium, lead, and total mercury in blood all showed a substantial decreasing exposure level tendency over the 16 years (all Pfor trend < 0.05). CHD prevalence varied from 3.53 to 5.23% between 2003 and 2018. The correlation between 15 heavy metals and CHD ranges from - 0.238 to 0.910. There was also a significant positive correlation between total arsenic, monomethylarsonic acid, and thallium in urine and CHD by data release cycles (all P < 0.05). The cesium in urine showed a negative correlation with CHD (P < 0.05). We found that exposure trends of total arsenic, dimethylarsonic acid, monomethylarsonic acid, barium, cadmium, lead, and antimony in urine and blood decreased. CHD prevalence fluctuated, however. Moreover, total arsenic, monomethylarsonic acid, and thallium in urine all showed positive relationships with CHD, while cesium in urine showed a negative relationship with CHD.

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来源期刊
Environmental Geochemistry and Health
Environmental Geochemistry and Health 环境科学-工程:环境
CiteScore
8.00
自引率
4.80%
发文量
279
审稿时长
4.2 months
期刊介绍: Environmental Geochemistry and Health publishes original research papers and review papers across the broad field of environmental geochemistry. Environmental geochemistry and health establishes and explains links between the natural or disturbed chemical composition of the earth’s surface and the health of plants, animals and people. Beneficial elements regulate or promote enzymatic and hormonal activity whereas other elements may be toxic. Bedrock geochemistry controls the composition of soil and hence that of water and vegetation. Environmental issues, such as pollution, arising from the extraction and use of mineral resources, are discussed. The effects of contaminants introduced into the earth’s geochemical systems are examined. Geochemical surveys of soil, water and plants show how major and trace elements are distributed geographically. Associated epidemiological studies reveal the possibility of causal links between the natural or disturbed geochemical environment and disease. Experimental research illuminates the nature or consequences of natural or disturbed geochemical processes. The journal particularly welcomes novel research linking environmental geochemistry and health issues on such topics as: heavy metals (including mercury), persistent organic pollutants (POPs), and mixed chemicals emitted through human activities, such as uncontrolled recycling of electronic-waste; waste recycling; surface-atmospheric interaction processes (natural and anthropogenic emissions, vertical transport, deposition, and physical-chemical interaction) of gases and aerosols; phytoremediation/restoration of contaminated sites; food contamination and safety; environmental effects of medicines; effects and toxicity of mixed pollutants; speciation of heavy metals/metalloids; effects of mining; disturbed geochemistry from human behavior, natural or man-made hazards; particle and nanoparticle toxicology; risk and the vulnerability of populations, etc.
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