semaphorins 在过敏性疾病中的作用

IF 6.2 2区 医学 Q1 ALLERGY Allergology International Pub Date : 2024-01-01 DOI:10.1016/j.alit.2023.08.006
Maiko Naito , Atsushi Kumanogoh
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引用次数: 0

摘要

半隐形蛋白最初被认为是神经发育过程中的引导分子。然而,越来越多的证据表明,"免疫隐形蛋白 "在调节免疫细胞的活化、分化、移动和迁移方面发挥着至关重要的作用。半隐形蛋白还与哮喘、过敏性鼻炎、特应性皮炎、过敏性结膜炎和嗜酸性慢性鼻炎等过敏性疾病的发病机制密切相关。有趣的是,在过敏性疾病患者体内,一些半合成蛋白的水平会升高,而另一些则会降低,这反映了它们在免疫细胞正负调节方面的功能。本综述介绍了免疫半合成蛋白在过敏性炎症中的致病功能,并讨论了这些分子作为过敏性疾病治疗靶点的潜在用途。
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The role of semaphorins in allergic diseases

Semaphorins were originally identified as guidance molecules in neural development. However, accumulating evidence indicates that ‘immune semaphorins’ are critically involved in regulating immune cell activation, differentiation, mobility and migration. Semaphorins are also intimately associated with the pathogenesis of allergic diseases including asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and eosinophilic chronic rhinosinusitis. Interestingly, reflecting their function in positive or negative regulation of immune cells, levels of some semaphorins are increased while others are decreased in patients with allergic diseases. This review presents the pathogenic functions of immune semaphorins in allergic inflammation and discusses the potential use of these molecules as therapeutic targets for allergic diseases.

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来源期刊
Allergology International
Allergology International ALLERGY-IMMUNOLOGY
CiteScore
12.60
自引率
5.90%
发文量
96
审稿时长
29 weeks
期刊介绍: Allergology International is the official journal of the Japanese Society of Allergology and publishes original papers dealing with the etiology, diagnosis and treatment of allergic and related diseases. Papers may include the study of methods of controlling allergic reactions, human and animal models of hypersensitivity and other aspects of basic and applied clinical allergy in its broadest sense. The Journal aims to encourage the international exchange of results and encourages authors from all countries to submit papers in the following three categories: Original Articles, Review Articles, and Letters to the Editor.
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